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    Amz2 archaelysin family metallopeptidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 13929, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Amz2provided by MGI
    Official Full Name
    archaelysin family metallopeptidase 2provided by MGI
    Primary source
    MGI:MGI:104837
    See related
    Ensembl:ENSMUSG00000020610 AllianceGenome:MGI:104837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM12
    Summary
    Predicted to enable metal ion binding activity and metallopeptidase activity. Predicted to be involved in proteolysis. Is expressed in several structures, including central nervous system; heart ventricle; and sensory organ. Orthologous to human AMZ2 (archaelysin family metallopeptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 71.6), CNS E18 (RPKM 55.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Amz2 in Genome Data Viewer
    Location:
    11 E1; 11 71.89 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109316772..109328974)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (109425946..109438148)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700096J18 gene Neighboring gene STARR-seq mESC enhancer starr_31020 Neighboring gene STARR-positive B cell enhancer ABC_E7086 Neighboring gene STARR-positive B cell enhancer ABC_E5291 Neighboring gene predicted gene 11696 Neighboring gene guanine nucleotide binding protein, alpha 13 Neighboring gene STARR-positive B cell enhancer ABC_E4009 Neighboring gene STARR-positive B cell enhancer ABC_E7087 Neighboring gene STARR-positive B cell enhancer mm9_chr11:109281499-109281800 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109287298-109287521 Neighboring gene STARR-positive B cell enhancer ABC_E380 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109293875-109294028 Neighboring gene STARR-positive B cell enhancer ABC_E10727 Neighboring gene STARR-positive B cell enhancer ABC_E5293 Neighboring gene predicted gene, 45916 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 6 Neighboring gene STARR-positive B cell enhancer ABC_E5294 Neighboring gene STARR-positive B cell enhancer ABC_E7088 Neighboring gene STARR-positive B cell enhancer ABC_E1846 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109357315-109357468 Neighboring gene arylsulfatase G Neighboring gene predicted gene, 22378

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    archaemetzincin-2
    Names
    archeobacterial metalloproteinase-like protein 2
    NP_001239122.1
    NP_079551.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252193.1 → NP_001239122.1  archaemetzincin-2

      See identical proteins and their annotated locations for NP_001239122.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK075748, AL645791, CA575133
      Consensus CDS
      CCDS25579.1
      UniProtKB/Swiss-Prot
      Q400C8, Q8BVM5, Q8K3B9, Q9D121
      UniProtKB/TrEMBL
      B1AT59
      Related
      ENSMUSP00000159063.2, ENSMUST00000238825.2
      Conserved Domains (1) summary
      cd11375
      Location:92 → 302
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

    2. NM_025275.4 → NP_079551.3  archaemetzincin-2

      See identical proteins and their annotated locations for NP_079551.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AL645791
      Consensus CDS
      CCDS25579.1
      UniProtKB/Swiss-Prot
      Q400C8, Q8BVM5, Q8K3B9, Q9D121
      UniProtKB/TrEMBL
      B1AT59
      Related
      ENSMUSP00000090157.5, ENSMUST00000092500.11
      Conserved Domains (1) summary
      cd11375
      Location:92 → 302
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      109316772..109328974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q400C8.1 GenPept UniProtKB/Swiss-Prot:Q400C8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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