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    npr2.L natriuretic peptide receptor 2 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 399350, updated on 4-Nov-2024

    Summary

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    Official Symbol
    npr2.L
    Official Full Name
    natriuretic peptide receptor 2 L homeolog
    Primary source
    Xenbase:XB-GENE-17337841
    See related
    EnsemblRapid:ENSXLAG00005001362 AllianceGenome:Xenbase:XB-GENE-17337841
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    addm; npr2; nprb; guc2b; npr-b; xgc-2; gucy2b
    Summary
    Predicted to enable several functions, including ATP binding activity; natriuretic peptide receptor activity; and phosphorus-oxygen lyase activity. Acts upstream of or within heart development. Predicted to be located in plasma membrane. Is expressed in ectoderm; musculoskeletal system; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See npr2.L in Genome Data Viewer
    Location:
    chromosome: 1L
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (232517138..232564367)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (218796158..218797315, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016704082.1 (356..968)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016755159.1 (1..326, complement)

    Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 8B Neighboring gene LOC100145065 L homeolog Neighboring gene uncharacterized LOC108719191 Neighboring gene uncharacterized LOC108719204 Neighboring gene RGP1 homolog, RAB6A GEF complex partner 1 L homeolog Neighboring gene sigma non-opioid intracellular receptor 1 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Npr3 regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor. Devotta A, et al. Elife, 2023 May 10. PMID 37162198, Free PMC Article
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables natriuretic peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heart development EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within receptor guanylyl cyclase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    natriuretic peptide receptor 2 L homeolog
    Names
    guanylyl cyclase-2
    natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001090707.1 → NP_001084176.1  natriuretic peptide receptor 2 L homeolog

      See identical proteins and their annotated locations for NP_001084176.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129689
      UniProtKB/TrEMBL
      A1L2S6, Q9PWG9
      Related
      ENSXLAP00005004134.1, ENSXLAT00005004200.1
      Conserved Domains (6) summary
      cd06384
      Location:60 → 457
      PBP1_NPR_B; Ligand-binding domain of type B natriuretic peptide receptor
      smart00044
      Location:861 → 1045
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:554 → 828
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:888 → 1074
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:78 → 436
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:837 → 882
      HNOBA; Heme NO binding associated

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      232517138..232564367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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