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    cep57l1.L centrosomal protein 57kDa-like 1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 734283, updated on 4-Nov-2024

    Summary

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    Official Symbol
    cep57l1.L
    Official Full Name
    centrosomal protein 57kDa-like 1 L homeolog
    Primary source
    Xenbase:XB-GENE-5897421
    Locus tag
    XELAEV_18027199mg
    See related
    EnsemblRapid:ENSXLAG00005034448 AllianceGenome:Xenbase:XB-GENE-5897421
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    cep57; XCep57; cep57r; cep57l1; c6orf182
    Summary
    Enables gamma-tubulin binding activity. Acts upstream of or within attachment of spindle microtubules to kinetochore. Located in centrosome; kinetochore; and spindle microtubule. Orthologous to human CEP57L1 (centrosomal protein 57 like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    See cep57l1.L in Genome Data Viewer
    Location:
    chromosome: 5L
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (81425245..81436724, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (79219983..79231379, complement)

    Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene sialomucin core protein 24 Neighboring gene coiled-coil domain containing 162 L homeolog Neighboring gene sestrin 1 L homeolog Neighboring gene armadillo repeat containing 2 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xenopus Cep57 is a novel kinetochore component involved in microtubule attachment. Emanuele MJ, et al. Cell, 2007 Sep 7. PMID 17803911
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC84957

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables gamma-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centrosomal protein cep57l1
    Names
    Centrosomal protein of 57 kDa
    Cep57-related protein
    centrosomal protein 57kDa
    centrosomal protein 57kDa-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001095767.1 → NP_001089236.1  centrosomal protein cep57l1

      See identical proteins and their annotated locations for NP_001089236.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089255
      UniProtKB/Swiss-Prot
      Q5FWP9
      UniProtKB/TrEMBL
      A0A974HJJ8
      Related
      ENSXLAP00005102983.1, ENSXLAT00005104987.1
      Conserved Domains (3) summary
      pfam01496
      Location:126 → 204
      V_ATPase_I; V-type ATPase 116kDa subunit family
      pfam06657
      Location:341 → 408
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:56 → 230
      Cep57_CLD; Centrosome localization domain of Cep57

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      81425245..81436724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FWP9.1 GenPept UniProtKB/Swiss-Prot:Q5FWP9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.