U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sae1.L SUMO1 activating enzyme subunit 1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 443558, updated on 4-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sae1.L
    Official Full Name
    SUMO1 activating enzyme subunit 1 L homeolog
    Primary source
    Xenbase:XB-GENE-923367
    Locus tag
    XELAEV_18039273mg
    See related
    EnsemblRapid:ENSXLAG00005028970 AllianceGenome:Xenbase:XB-GENE-923367
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    aos; sae1; Aos1p; Sua1p; uble1a
    Summary
    Predicted to enable ubiquitin-like modifier activating enzyme activity. Predicted to contribute to SUMO activating enzyme activity. Predicted to act upstream of or within protein sumoylation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of SUMO activating enzyme complex. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sae1.L in Genome Data Viewer
    Location:
    chromosome: 8L
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (68751680..68782410, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (55252790..55283647, complement)

    Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 9 L homeolog Neighboring gene uncharacterized XB22065716 L homeolog Neighboring gene zinc finger CCCH-type containing 4 L homeolog Neighboring gene provisional ortholog of CDC42 effector protein 2 L homeolog

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Protein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress. Wang F, et al. Sci Rep, 2018 Feb 8. PMID 29422626, Free PMC Article
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC78909

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables SUMO activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to SUMO activating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein modification by small protein conjugation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SUMO activating enzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SUMO activating enzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    SUMO-activating enzyme subunit 1
    Names
    SUMO-1 activating enzyme E1 N subunit
    SUMO-activating enzyme E1 N subunit
    ubiquitin-like 1-activating enzyme E1A

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001091789.1 → NP_001085258.1  SUMO-activating enzyme subunit 1

      See identical proteins and their annotated locations for NP_001085258.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086263
      UniProtKB/Swiss-Prot
      Q8JGT5
      UniProtKB/TrEMBL
      A0A974C7P9
      Related
      ENSXLAP00005086428.1, ENSXLAT00005088090.1
      Conserved Domains (2) summary
      cd01492
      Location:14 → 339
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:17 → 165
      ThiF; ThiF family

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      68751680..68782410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018228860.2 → XP_018084349.1  SUMO-activating enzyme subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8J0TEN4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JGT5.1 GenPept UniProtKB/Swiss-Prot:Q8JGT5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials