clcn3.S chloride channel, voltage-sensitive 3 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: clcn3.S
Official Full Name: chloride channel, voltage-sensitive 3 S homeolog
Primary source: Xenbase:XB-GENE-950797
Locus tag: XELAEV_18009167mg
See related: EnsemblRapid:ENSXLAG00005001190 AllianceGenome:Xenbase:XB-GENE-950797
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: clc3; clc-3; clcn3
Summary: Predicted to enable voltage-gated chloride channel activity. Predicted to act upstream of or within chloride transport and transmembrane transport. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and lysosomal membrane. Orthologous to human CLCN3 (chloride voltage-gated channel 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1S

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1S	NC_054372.1 (39095856..39143183, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1S	NC_030725.1 (38837255..38884614, complement)

Chromosome 1S - NC_054372.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A local enhancement of CIC-3 expression at the leading edge of the wounded epidermis was found to be specific to closing wounds.
Title: Possible roles of ENaC and Cl(-) channel in wound closure in Xenopus laevis embryos.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables voltage-gated chloride channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chloride channel, voltage-sensitive 3 S homeolog

Names: chloride channel 3; putative chloride channel ClC-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090267.1 → NP_001083736.1 chloride channel, voltage-sensitive 3 S homeolog

See identical proteins and their annotated locations for NP_001083736.1

Status: PROVISIONAL

Source sequence(s)

Y09941

UniProtKB/TrEMBL

A0A974I0I9, A5PKR3, Q9YH11

Related

ENSXLAP00005003635.1, ENSXLAT00005003697.1

Conserved Domains (4) summary

COG0517
Location:628 → 774

CBS; CBS domain [Signal transduction mechanisms]

cd03684
Location:109 → 615

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:638 → 776

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...

pfam00654
Location:194 → 595

Voltage_CLC; Voltage gated chloride channel

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

39095856..39143183 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)