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    raf1.S Raf-1 proto-oncogene, serine/threonine kinase S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 397857, updated on 17-Aug-2024

    Summary

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    Official Symbol
    raf1.S
    Official Full Name
    Raf-1 proto-oncogene, serine/threonine kinase S homeolog
    Primary source
    Xenbase:XB-GENE-6053397
    Locus tag
    XELAEV_18002603mg
    See related
    EnsemblRapid:ENSXLAG00005000080
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    raf; craf; raf1; c-raf; raf-1
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    Genomic context

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    See raf1.S in Genome Data Viewer
    Location:
    chromosome: 4S
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (132212871..132256660)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694823.1 (2018394..2044316)

    Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene synapsin II S homeolog Neighboring gene metalloproteinase inhibitor 4 Neighboring gene peroxisome proliferator activated receptor gamma S homeolog Neighboring gene E3 ubiquitin/ISG15 ligase TRIM25-like Neighboring gene E3 ubiquitin-protein ligase TRIM7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of Xenopus C-raf coding region. Le Guellec R, et al. Nucleic Acids Res, 1988 Nov 11. PMID 3194203, Free PMC Article
    2. Xenopus c-raf proto-oncogene: cloning and expression during oogenesis and early development. Le Guellec R, et al. Biol Cell, 1991. PMID 1721855
    3. B-Raf and C-Raf are required for Ras-stimulated p42 MAP kinase activation in Xenopus egg extracts. Yue J, et al. Oncogene, 2006 Jun 1. PMID 16434971
    4. Cation diffusion facilitator proteins modulate Raf-1 activity. Jirakulaporn T, et al. J Biol Chem, 2004 Jun 25. PMID 15096503
    5. RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis. Wong S, et al. EMBO Mol Med, 2023 May 8. PMID 37066513, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis.
      Title: RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis.
    2. Both c-Raf and B-Raf are required for Ras-induced MEK1 and p42 MAP kinase activation.
      Title: B-Raf and C-Raf are required for Ras-stimulated p42 MAP kinase activation in Xenopus egg extracts.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RAF proto-oncogene serine/threonine-protein kinase
    NP_001081475.1
    XP_041447151.1
    XP_041447152.1
    XP_041447153.1
    XP_041447154.1
    XP_041447155.1
    XP_041447156.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001088006.1 → NP_001081475.1  RAF proto-oncogene serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_001081475.1

      Status: PROVISIONAL

      Source sequence(s)
      BC072748
      UniProtKB/Swiss-Prot
      P09560, Q91390
      UniProtKB/TrEMBL
      Q6GQJ4
      Conserved Domains (4) summary
      cd01816
      Location:57 → 130
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14149
      Location:327 → 609
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00069
      Location:341 → 596
      Pkinase; Protein kinase domain
      pfam00130
      Location:138 → 186
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      132212871..132256660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041591222.1 → XP_041447156.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

      UniProtKB/Swiss-Prot
      P09560, Q91390
      UniProtKB/TrEMBL
      A0A8J1N097
      Conserved Domains (3) summary
      smart00109
      Location:138 → 183
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd14149
      Location:318 → 600
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 130
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

    2. XM_041591218.1 → XP_041447152.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      P09560, Q91390
      UniProtKB/TrEMBL
      A0A8J1N100
      Conserved Domains (3) summary
      smart00109
      Location:138 → 183
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd14149
      Location:370 → 652
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 130
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

    3. XM_041591217.1 → XP_041447151.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      P09560, Q91390
      UniProtKB/TrEMBL
      A0A8J1N100
      Conserved Domains (3) summary
      smart00109
      Location:138 → 183
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd14149
      Location:370 → 652
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 130
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

    4. XM_041591221.1 → XP_041447155.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

      UniProtKB/Swiss-Prot
      P09560, Q91390
      UniProtKB/TrEMBL
      A0A8J1N1S1
      Conserved Domains (3) summary
      smart00109
      Location:138 → 183
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd14149
      Location:347 → 629
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 130
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

    5. XM_041591220.1 → XP_041447154.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      UniProtKB/Swiss-Prot
      P09560, Q91390
      UniProtKB/TrEMBL
      A0A8J1MZ40
      Related
      ENSXLAP00005000152.1, ENSXLAT00005000176.1
      Conserved Domains (3) summary
      smart00109
      Location:138 → 183
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd14149
      Location:350 → 632
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 130
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

    6. XM_041591219.1 → XP_041447153.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      P09560, Q91390
      UniProtKB/TrEMBL
      A0A8J1N100
      Conserved Domains (3) summary
      smart00109
      Location:138 → 183
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd14149
      Location:370 → 652
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 130
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09560.1 GenPept UniProtKB/Swiss-Prot:P09560

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