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    eef1a1o.S eukaryotic translation elongation factor 1 alpha 1, oocyte form S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 379289, updated on 4-Nov-2024

    Summary

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    Official Symbol
    eef1a1o.S
    Official Full Name
    eukaryotic translation elongation factor 1 alpha 1, oocyte form S homeolog
    Primary source
    Xenbase:XB-GENE-17330483
    Locus tag
    XELAEV_18004064mg
    See related
    EnsemblRapid:ENSXLAG00005004870 AllianceGenome:Xenbase:XB-GENE-17330483
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    42Sp48; EF-1aO; xef1ao; eef1a-o1; EF-1-alpha-O; EF-1-ALPHA-O1
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and translation elongation factor activity. Predicted to act upstream of or within translational elongation. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See eef1a1o.S in Genome Data Viewer
    Location:
    chromosome: 2S
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (82679654..82683857, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694858.1 (607467..611673, complement)

    Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene elongin A S homeolog Neighboring gene ribosomal protein L11 S homeolog Neighboring gene palmitoyl-protein thioesterase 1 S homeolog Neighboring gene cyclase associated actin cytoskeleton regulatory protein 1 S homeolog Neighboring gene major facilitator superfamily domain containing 2A S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary importance of translation elongation factor eEF1A variant switching: eEF1A1 down-regulation in muscle is conserved in Xenopus but is controlled at a post-transcriptional level. Newbery HJ, et al. Biochem Biophys Res Commun, 2011 Jul 22. PMID 21722626
    2. Isolation and characterization of the gene encoding EF-1 alpha O, an elongation factor 1-alpha expressed during early development of Xenopus laevis. Frydenberg J, et al. Gene, 1991 Dec 30. PMID 1765266
    3. Three genes under different developmental control encode elongation factor 1-alpha in Xenopus laevis. Djé MK, et al. Nucleic Acids Res, 1990 Jun 25. PMID 2362804, Free PMC Article
    4. 42Sp48 in previtellogenic Xenopus oocytes is structurally homologous to EF-1 alpha and may be a stage-specific elongation factor. Coppard NJ, et al. J Cell Biol, 1991 Jan. PMID 1988459, Free PMC Article
    5. Two forms of elongation factor 1 alpha (EF-1 alpha O and 42Sp50), present in oocytes, but absent in somatic cells of Xenopus laevis. Deschamps S, et al. J Cell Biol, 1991 Sep. PMID 1894690, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. isoform switching in Xenopus laevis may have evolved because of a need for certain cell types to modify the well-established non-canonical functions of eEF1A1.
      Title: Evolutionary importance of translation elongation factor eEF1A variant switching: eEF1A1 down-regulation in muscle is conserved in Xenopus but is controlled at a post-transcriptional level.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC53846

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    elongation factor 1-alpha, oocyte form
    Names
    EF-1AO1
    elongation factor 1 alpha, oocyte form
    elongation factor Tu

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001086133.1 → NP_001079602.1  elongation factor 1-alpha, oocyte form

      See identical proteins and their annotated locations for NP_001079602.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045083
      UniProtKB/Swiss-Prot
      P17508
      UniProtKB/TrEMBL
      A0A8J0PNX7, A0A974BSC7, A0AA97PZ01, Q7ZXA2
      Related
      ENSXLAP00005014532.1, ENSXLAT00005014728.1
      Conserved Domains (4) summary
      PTZ00141
      Location:1 → 461
      PTZ00141; elongation factor 1- alpha; Provisional
      cd01883
      Location:9 → 239
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      cd03693
      Location:242 → 332
      EF1_alpha_II; Domain II of elongation factor 1-alpha
      cd03705
      Location:335 → 438
      EF1_alpha_III; Domain III of Elongation Factor 1

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      82679654..82683857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17508.2 GenPept UniProtKB/Swiss-Prot:P17508

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials