ubr5 ubiquitin protein ligase E3 component n-recognin 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ubr5provided by ZNC
Official Full Name: ubiquitin protein ligase E3 component n-recognin 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6559
See related: Ensembl:ENSDARG00000018192 AllianceGenome:ZFIN:ZDB-GENE-030131-6559
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: edd1; wu:fa16c12
Summary: Predicted to enable ubiquitin-ubiquitin ligase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway and protein polyubiquitination. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer (multiple) and carcinoma (multiple). Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 16

Exon count:: 58

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (52542033..52646937, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (52656290..52761280, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fa16c12.s1 (e-PCR)
- UniSTS:202399

fb78g11.x1 (e-PCR)
- UniSTS:203444

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-ubiquitin ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: E3 ubiquitin-protein ligase UBR5

Names: E3 ubiquitin protein ligase, HECT domain containing, 1

NP_001157866.1

EC 2.3.2.26

XP_005158494.1

EC 2.3.2.26

XP_005158497.1

EC 2.3.2.26

XP_021322301.1

EC 2.3.2.26

XP_021322302.1

EC 2.3.2.26

XP_021322303.1

EC 2.3.2.26

XP_021322304.1

EC 2.3.2.26

XP_021322305.1

EC 2.3.2.26

XP_021322306.1

EC 2.3.2.26

XP_068070007.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164394.1 → NP_001157866.1 E3 ubiquitin-protein ligase UBR5

Status: PROVISIONAL

Source sequence(s)

CR293507

UniProtKB/TrEMBL

A0A8M1NV16

Related

ENSDARP00000033510.7, ENSDART00000035761.9

Conserved Domains (5) summary

smart00396
Location:1180 → 1247

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

smart00517
Location:2384 → 2447

PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein

smart00119
Location:2466 → 2791

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00632
Location:2496 → 2794

HECT; HECT-domain (ubiquitin-transferase)

pfam11547
Location:179 → 226

E3_UbLigase_EDD; E3 ubiquitin ligase EDD

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

52542033..52646937 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021466631.2 → XP_021322306.1 E3 ubiquitin-protein ligase UBR5 isoform X8

UniProtKB/TrEMBL

A0A8M9PJA4

Conserved Domains (4) summary

smart00396
Location:1167 → 1234

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

smart00517
Location:2383 → 2446

PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein

smart00119
Location:2465 → 2790

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam11547
Location:166 → 213

E3_UbLigase_EDD; E3 ubiquitin ligase EDD
XM_005158440.5 → XP_005158497.1 E3 ubiquitin-protein ligase UBR5 isoform X9

UniProtKB/TrEMBL

A0A8M2B4T2

Conserved Domains (5) summary

smart00396
Location:1201 → 1268

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

smart00517
Location:2406 → 2469

PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein

smart00119
Location:2488 → 2813

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00632
Location:2518 → 2816

HECT; HECT-domain (ubiquitin-transferase)

pfam11547
Location:206 → 253

E3_UbLigase_EDD; E3 ubiquitin ligase EDD
XM_021466629.2 → XP_021322304.1 E3 ubiquitin-protein ligase UBR5 isoform X4

UniProtKB/TrEMBL

A0A8M9PCY7

Conserved Domains (4) summary

smart00396
Location:1201 → 1268

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

smart00517
Location:2417 → 2480

PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein

smart00119
Location:2499 → 2824

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam11547
Location:206 → 253

E3_UbLigase_EDD; E3 ubiquitin ligase EDD
XM_021466627.2 → XP_021322302.1 E3 ubiquitin-protein ligase UBR5 isoform X2

UniProtKB/TrEMBL

A0A8M9NZ45

Conserved Domains (4) summary

smart00396
Location:1206 → 1273

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

smart00517
Location:2422 → 2485

PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein

smart00119
Location:2504 → 2829

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam11547
Location:206 → 253

E3_UbLigase_EDD; E3 ubiquitin ligase EDD
XM_021466630.2 → XP_021322305.1 E3 ubiquitin-protein ligase UBR5 isoform X6

UniProtKB/TrEMBL

A0A8M9PM86

Conserved Domains (4) summary

smart00396
Location:1207 → 1274

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

smart00517
Location:2412 → 2475

PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein

smart00119
Location:2494 → 2819

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam11547
Location:206 → 253

E3_UbLigase_EDD; E3 ubiquitin ligase EDD
XM_068213906.1 → XP_068070007.1 E3 ubiquitin-protein ligase UBR5 isoform X7
XM_021466628.2 → XP_021322303.1 E3 ubiquitin-protein ligase UBR5 isoform X3

UniProtKB/TrEMBL

A0A8M9P7S4

Conserved Domains (4) summary

smart00396
Location:1207 → 1274

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

smart00517
Location:2418 → 2481

PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein

smart00119
Location:2500 → 2825

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam11547
Location:206 → 253

E3_UbLigase_EDD; E3 ubiquitin ligase EDD
XM_005158437.5 → XP_005158494.1 E3 ubiquitin-protein ligase UBR5 isoform X5

UniProtKB/TrEMBL

A0A8M2B598

Conserved Domains (5) summary

smart00396
Location:1207 → 1274

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

smart00517
Location:2412 → 2475

PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein

smart00119
Location:2494 → 2819

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00632
Location:2524 → 2822

HECT; HECT-domain (ubiquitin-transferase)

pfam11547
Location:206 → 253

E3_UbLigase_EDD; E3 ubiquitin ligase EDD
XM_021466626.2 → XP_021322301.1 E3 ubiquitin-protein ligase UBR5 isoform X1

UniProtKB/TrEMBL

A0A8M9PJ96

Conserved Domains (4) summary

smart00396
Location:1207 → 1274

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

smart00517
Location:2423 → 2486

PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein

smart00119
Location:2505 → 2830

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam11547
Location:206 → 253

E3_UbLigase_EDD; E3 ubiquitin ligase EDD