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    zdhhc13 zinc finger DHHC-type palmitoyltransferase 13 [ Danio rerio (zebrafish) ]

    Gene ID: 494107, updated on 11-Apr-2024

    Summary

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    Official Symbol
    zdhhc13provided by ZNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 13provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-79
    See related
    Ensembl:ENSDARG00000101144 AllianceGenome:ZFIN:ZDB-GENE-041212-79
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    DHHC-13; fi22e09; wu:fb06e01; wu:fc39g10; wu:fi22e09; zgc:101690
    Summary
    Predicted to enable palmitoyltransferase activity. Acts upstream of or within BMP signaling pathway involved in mesodermal cell fate specification; regulation of BMP signaling pathway; and regulation of ectodermal cell fate specification. Predicted to be located in Golgi apparatus and cytoplasmic vesicle membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Is expressed in blastoderm; blastomere; and head. Orthologous to human ZDHHC13 (zinc finger DHHC-type palmitoyltransferase 13). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See zdhhc13 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (16509245..16546131)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (16257272..16294158)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene bloodthirsty-related gene family, member 6 Neighboring gene bloodthirsty-related gene family, member 7 Neighboring gene metallophosphoesterase domain containing 2a Neighboring gene transfer RNA arginine (anticodon UCG) Neighboring gene cysteine and glycine-rich protein 3 (cardiac LIM protein)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zinc finger DHHC-type containing 13 regulates fate specification of ectoderm and mesoderm cell lineages by modulating Smad6 activity. Chen X, et al. Stem Cells Dev, 2014 Aug 15. PMID 24702307
    2. Evolution of the vertebrate Pax4/6 class of genes with focus on its novel member, the Pax10 gene. Feiner N, et al. Genome Biol Evol, 2014 Jun 19. PMID 24951566, Free PMC Article
    3. 2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Wang C, et al. Neurotoxicol Teratol, 2015 Jul-Aug. PMID 26056731
    4. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of ectodermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative palmitoyltransferase ZDHHC13
    Names
    DHHC domain-containing protein 13
    palmitoyltransferase ZDHHC13
    zinc finger DHHC domain-containing protein 13
    zinc finger DHHC-type containing 13
    NP_001008650.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008650.3 → NP_001008650.2  putative palmitoyltransferase ZDHHC13

      Status: VALIDATED

      Source sequence(s)
      CU041375, EH546849, EH547414
      UniProtKB/Swiss-Prot
      A0A0R4IQZ2, Q5PRB8
      Related
      ENSDARP00000142710.1, ENSDART00000173777.2
      Conserved Domains (4) summary
      PHA03095
      Location:115 → 312
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:62 → 204
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:76 → 102
      ANK; ANK repeat [structural motif]
      pfam01529
      Location:450 → 580
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      16509245..16546131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0R4IQZ2.1 GenPept UniProtKB/Swiss-Prot:A0A0R4IQZ2

    Gene LinkOut

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