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    cyp3c3 cytochrome P450, family 3, subfamily c, polypeptide 3 [ Danio rerio (zebrafish) ]

    Gene ID: 492759, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cyp3c3provided by ZNC
    Official Full Name
    cytochrome P450, family 3, subfamily c, polypeptide 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-102
    See related
    Ensembl:ENSDARG00000037873 AllianceGenome:ZFIN:ZDB-GENE-041114-102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cyp3c1l2; zgc:101781
    Summary
    Predicted to enable steroid hydroxylase activity. Predicted to be located in membrane. Is expressed in several structures, including adaxial cell; heart; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A43 (cytochrome P450 family 3 subfamily A member 43); and CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cyp3c3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (40947961..40955782, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (40806103..40813924, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene forkhead box K1 Neighboring gene cytochrome P450, family 3, subfamily C, polypeptide 4 Neighboring gene cytochrome P450, family 3, subfamily c, polypeptide 2 Neighboring gene cytochrome P450, family 3, subfamily c, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression patterns of cytochrome P450 3B and 3C genes in model fish species. Shaya L, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2014 Nov. PMID 25073111
    2. CYP3C1, the first member of a new cytochrome P450 subfamily found in zebrafish (Danio rerio). Corley-Smith GE, et al. Biochem Biophys Res Commun, 2006 Feb 24. PMID 16414346
    3. CYP3C gene regulation by the aryl hydrocarbon and estrogen receptors in zebrafish. Shaya L, et al. Toxicol Appl Pharmacol, 2019 Jan 1. PMID 30393146
    4. Rapid birth-death evolution specific to xenobiotic cytochrome P450 genes in vertebrates. Thomas JH. PLoS Genet, 2007 May 11. PMID 17500592, Free PMC Article
    5. Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish. Nawaji T, et al. Pharmaceuticals (Basel), 2020 Dec 11. PMID 33322603, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steroid hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 3C3
    Names
    cytochrome P450, family 3, subfamily c, polypeptide 1 like, 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007400.2 → NP_001007401.2  cytochrome P450 3C3

      Status: VALIDATED

      Source sequence(s)
      BX649536
      UniProtKB/TrEMBL
      A0A8M6Z4Z2, E7EY99
      Related
      ENSDARP00000109527.2, ENSDART00000130130.4
      Conserved Domains (1) summary
      pfam00067
      Location:38 → 496
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      40947961..40955782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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