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    kpnb1 karyopherin (importin) beta 1 [ Danio rerio (zebrafish) ]

    Gene ID: 570700, updated on 2-Nov-2024

    Summary

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    Official Symbol
    kpnb1provided by ZNC
    Official Full Name
    karyopherin (importin) beta 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2579
    See related
    Ensembl:ENSDARG00000104889 AllianceGenome:ZFIN:ZDB-GENE-030131-2579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc12b10; zgc:123184
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within intracellular protein transport. Predicted to be active in cytoplasm and nucleus. Is expressed in digestive system; nervous system; and neural keel. Orthologous to human KPNB1 (karyopherin subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kpnb1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (48024457..48037723)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (48364180..48377446)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene zgc:158376 Neighboring gene E3 ubiquitin-protein ligase TRIM11 Neighboring gene si:ch1073-205c8.3 Neighboring gene small nucleolar RNA SNORA79 Neighboring gene colony stimulating factor 3 (granulocyte) b Neighboring gene proteasome 26S subunit, non-ATPase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. High level of GHR nuclear translocation in skeletal muscle of a hyperplasic transgenic zebrafish. Figueiredo MA, et al. J Mol Endocrinol, 2016 Jan. PMID 26553237
    2. Requirement of nuclear localization and transcriptional activity of p53 for its targeting to the yolk syncytial layer (YSL) nuclei in zebrafish embryo and its use for apoptosis assay. Chen GD, et al. Biochem Biophys Res Commun, 2006 May 26. PMID 16616005
    3. Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins. Zeng J, et al. Nucleic Acids Res, 2008 Jan. PMID 18086703, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123184

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    importin subunit beta-1
    Names
    karyopherin beta 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037702.3 → NP_001032791.3  importin subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      CU929079
      UniProtKB/TrEMBL
      A0A0R4IMZ8, A0A8M1N881
      Related
      ENSDARP00000135519.1, ENSDART00000163823.2
      Conserved Domains (4) summary
      COG5215
      Location:2 → 871
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      cd00020
      Location:365 → 479
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam03810
      Location:21 → 101
      IBN_N; Importin-beta N-terminal domain
      sd00044
      Location:323 → 354
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      48024457..48037723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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