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    cbfb core-binding factor subunit beta [ Danio rerio (zebrafish) ]

    Gene ID: 30744, updated on 10-Sep-2024

    Summary

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    Official Symbol
    cbfbprovided by ZNC
    Official Full Name
    core-binding factor subunit betaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-440
    See related
    Ensembl:ENSDARG00000040917 AllianceGenome:ZFIN:ZDB-GENE-980526-440
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    unp1266
    Summary
    Enables protein heterodimerization activity. Contributes to DNA binding activity and transcription coregulator activity. Acts upstream of or within several processes, including heart contraction; lymphoid lineage cell migration into thymus; and myofibril assembly. Located in Z disc and nucleus. Part of core-binding activity factor complex. Is expressed in several structures, including digestive system; ganglia; hematopoietic system; immune system; and pericardial region. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CBFB (core-binding factor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 18
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (22993940..23072665)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (23004885..23082244)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor 4 Neighboring gene guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a Neighboring gene uncharacterized LOC108179979 Neighboring gene uncharacterized LOC103909137 Neighboring gene myocyte enhancer factor 2aa Neighboring gene multiple C2 domains, transmembrane 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of cbfβ gene and identification of new transcription variants: implications for function. Simões B, et al. Arch Biochem Biophys, 2015 Feb 1. PMID 25575784
    2. JunB-CBFbeta signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure. Meder B, et al. J Cell Sci, 2010 Aug 1. PMID 20605922
    3. Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors. Tenno M, et al. J Exp Med, 2018 Feb 5. PMID 29343500, Free PMC Article
    4. Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors. Marques CL, et al. Gene, 2016 Jan 15. PMID 26456102
    5. Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blake T, et al. Blood, 2000 Dec 15. PMID 11110689

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. As in mice, an alternative splicing event in zebrafish generates a Cbfbeta2-specific mRNA, important for ccr9 expression. Thus, despite phylogenetically and ontogenetically variable sites of origin of T cell progenitors, their robust thymus-homing capacity is ensured by an evolutionarily conserved mechanism.
      Title: Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors.
    2. In neuronal fate determination, Runx co-factor Cbfbeta is essential for its function, but the high level of Runx3 expression can overcome the loss of Cbfbeta, demonstrating that Cbfbeta in this context serves solely as a signal amplifier of Runx3 activity.
      Title: An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish.
    3. characterization of cbfbeta gene
      Title: Molecular characterization of cbfβ gene and identification of new transcription variants: implications for function.
    4. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development
      Title: CBFβ and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish.
    5. Data demonstrate for the first time an essential role of JunB-CBFbeta signaling for maintaining sarcomere architecture and function.
      Title: JunB-CBFbeta signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    contributes_to DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lymphoid lineage cell migration into thymus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sarcomerogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of core-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core-binding factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    core-binding factor subunit beta
    Names
    CCAAT-binding transcription factor subunit B
    core-binding factor, beta subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199209.1 → NP_954679.1  core-binding factor subunit beta

      See identical proteins and their annotated locations for NP_954679.1

      Status: PROVISIONAL

      Source sequence(s)
      AF278758
      UniProtKB/TrEMBL
      A0A0B4P516, A0A0R4IV13, Q98U16
      Related
      ENSDARP00000138911.2, ENSDART00000171871.3
      Conserved Domains (1) summary
      pfam02312
      Location:1 → 162
      CBF_beta; Core binding factor beta subunit

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      22993940..23072665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467588.1 → XP_021323263.1  core-binding factor subunit beta isoform X3

      UniProtKB/TrEMBL
      A0A0B4P4A4, A0A0B4PIF9, A0A140LGH3
      Conserved Domains (1) summary
      pfam02312
      Location:1 → 162
      CBF_beta; Core binding factor beta subunit

    2. XM_021467589.1 → XP_021323264.1  core-binding factor subunit beta isoform X4

      UniProtKB/TrEMBL
      A0A0B4PIS7, A0A8M3AJI5
      Conserved Domains (1) summary
      pfam02312
      Location:1 → 162
      CBF_beta; Core binding factor beta subunit

    3. XM_005159048.4 → XP_005159105.1  core-binding factor subunit beta isoform X3

      See identical proteins and their annotated locations for XP_005159105.1

      UniProtKB/TrEMBL
      A0A0B4P4A4, A0A0B4PIF9, A0A140LGH3
      Conserved Domains (1) summary
      pfam02312
      Location:1 → 162
      CBF_beta; Core binding factor beta subunit

    4. XM_009293530.3 → XP_009291805.1  core-binding factor subunit beta isoform X1

      UniProtKB/TrEMBL
      A0A140LGT1, A0A8M3ARW3
      Conserved Domains (1) summary
      pfam02312
      Location:1 → 162
      CBF_beta; Core binding factor beta subunit

    5. XM_021467590.1 → XP_021323265.1  core-binding factor subunit beta isoform X5

      UniProtKB/TrEMBL
      A0A8M9PQ04
      Conserved Domains (1) summary
      pfam02312
      Location:1 → 162
      CBF_beta; Core binding factor beta subunit

    6. XM_005159047.4 → XP_005159104.1  core-binding factor subunit beta isoform X2

      UniProtKB/TrEMBL
      A0A8M2B5H7
      Conserved Domains (1) summary
      pfam02312
      Location:1 → 162
      CBF_beta; Core binding factor beta subunit

    7. XM_009293532.3 → XP_009291807.1  core-binding factor subunit beta isoform X4

      See identical proteins and their annotated locations for XP_009291807.1

      UniProtKB/TrEMBL
      A0A0B4PIS7, A0A8M3AJI5
      Conserved Domains (1) summary
      pfam02312
      Location:1 → 162
      CBF_beta; Core binding factor beta subunit

    8. XM_021467591.1 → XP_021323266.1  core-binding factor subunit beta isoform X6

      UniProtKB/TrEMBL
      A0A0B4P506, A0A8M9PLY2
      Conserved Domains (1) summary
      pfam02312
      Location:1 → 162
      CBF_beta; Core binding factor beta subunit

    9. XM_005159049.4 → XP_005159106.1  core-binding factor subunit beta isoform X6

      See identical proteins and their annotated locations for XP_005159106.1

      UniProtKB/TrEMBL
      A0A0B4P506, A0A8M9PLY2
      Conserved Domains (1) summary
      pfam02312
      Location:1 → 162
      CBF_beta; Core binding factor beta subunit

    RNA

    1. XR_002455999.1 RNA Sequence

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395026.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      184880..201412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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