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    fam49ba family with sequence similarity 49 member Ba [ Danio rerio (zebrafish) ]

    Gene ID: 337591, updated on 2-Nov-2024

    Summary

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    Official Symbol
    fam49baprovided by ZNC
    Official Full Name
    family with sequence similarity 49 member Baprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9537
    See related
    Ensembl:ENSDARG00000020929 AllianceGenome:ZFIN:ZDB-GENE-030131-9537
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fam49b; fj85c11; zgc:64118; wu:fj85c11
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in positive regulation of T cell activation. Predicted to act upstream of or within regulation of actin filament polymerization. Predicted to be located in membrane. Is expressed in epidermis; periderm; pharyngeal arch 3-7 skeleton; and pronephros. Orthologous to human CYRIB (CYFIP related Rac1 interactor B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See fam49ba in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (32215272..32262287, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (32232054..32279069, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100003868 Neighboring gene uncharacterized LOC137487932 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a Neighboring gene upstream binding transcription factor, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC337591
    Names
    family with sequence similarity 49, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291713.1 → NP_001278642.1  uncharacterized protein LOC337591 isoform 2

      See identical proteins and their annotated locations for NP_001278642.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame alternate exons in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      BC053261, EB764522, EH541135
      UniProtKB/TrEMBL
      A0A8M1P645, Q7T343
      Related
      ENSDARP00000056620.4, ENSDART00000056621.6
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 251
      DUF1394; Protein of unknown function (DUF1394)

    2. NM_200070.3 → NP_956364.2  uncharacterized protein LOC337591 isoform 1

      See identical proteins and their annotated locations for NP_956364.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      DT055468, EB764522, EH507686, EH541135
      UniProtKB/TrEMBL
      A0A8N7UZY6, Q6TLE5
      Related
      ENSDARP00000039716.4, ENSDART00000039717.6
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      32215272..32262287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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