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    tuba8l4 tubulin, alpha 8 like 4 [ Danio rerio (zebrafish) ]

    Gene ID: 393154, updated on 12-Sep-2024

    Summary

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    Official Symbol
    tuba8l4provided by ZNC
    Official Full Name
    tubulin, alpha 8 like 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-860
    See related
    Ensembl:ENSDARG00000006260 AllianceGenome:ZFIN:ZDB-GENE-040426-860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa93f03; zgc:55990; zgc:85669; wu:fa93f03
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within microtubule-based process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See tuba8l4 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (6972958..6976107, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (6815789..6818938, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor 4b Neighboring gene protein kinase Npk Neighboring gene si:ch211-114n24.6 Neighboring gene bridging integrator 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change. Sakamaki K, et al. Biochem Biophys Rep, 2015 Sep. PMID 29124180, Free PMC Article
    2. Nonsense mutation in the WDR73 gene is associated with Galloway-Mowat syndrome. Ben-Omran T, et al. J Med Genet, 2015 Jun. PMID 25873735
    3. Reproductive toxicity of β-diketone antibiotic mixtures to zebrafish (Danio rerio). Wang X, et al. Ecotoxicol Environ Saf, 2017 Jul. PMID 28342328
    4. Proteomic analysis of zebrafish (Danio rerio) infected with infectious spleen and kidney necrosis virus. Xiong XP, et al. Dev Comp Immunol, 2011 Apr. PMID 21075138
    5. 4.1Ba is necessary for glutamatergic synapse formation in the sensorimotor circuit of developing zebrafish. Fierro J Jr, et al. PLoS One, 2018. PMID 30286167, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55990

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tubulin, alpha 8 like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200185.1 → NP_956479.1  tubulin, alpha 8 like 4

      See identical proteins and their annotated locations for NP_956479.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045847
      UniProtKB/TrEMBL
      Q7ZVI6
      Related
      ENSDARP00000029933.7, ENSDART00000039443.9
      Conserved Domains (2) summary
      PTZ00335
      Location:1 → 440
      PTZ00335; tubulin alpha chain; Provisional
      cd02186
      Location:2 → 435
      alpha_tubulin; The alpha-tubulin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      6972958..6976107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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