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    dnm1l dynamin 1-like [ Danio rerio (zebrafish) ]

    Gene ID: 393896, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dnm1lprovided by ZNC
    Official Full Name
    dynamin 1-likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1556
    See related
    Ensembl:ENSDARG00000015006 AllianceGenome:ZFIN:ZDB-GENE-040426-1556
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    drp1; zgc:66163
    Summary
    Predicted to enable GTPase activity; microtubule binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrion organization; peroxisome fission; and protein complex oligomerization. Predicted to act upstream of or within rhythmic process. Predicted to be located in cytosol; mitochondrial outer membrane; and peroxisome. Predicted to be active in membrane; microtubule; and mitochondrion. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (dynamin 1 like). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dnm1l in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (20229573..20258638, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (20131919..20160997, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene caldesmon 1b Neighboring gene uncharacterized LOC103909847 Neighboring gene troponin T2d, cardiac Neighboring gene si:dkey-219c3.2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B9a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Optic nerve injury-induced regeneration in the adult zebrafish is accompanied by spatiotemporal changes in mitochondrial dynamics. Beckers A, et al. Neural Regen Res, 2023 Jan. PMID 35799546, Free PMC Article
    2. Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28. Moran AL, et al. FASEB J, 2022 May. PMID 35471581, Free PMC Article
    3. Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons. Drerup CM, et al. Elife, 2017 Apr 17. PMID 28414272, Free PMC Article
    4. TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology. Chen S, et al. Mol Cell, 2020 Dec 3. PMID 33171123
    5. Opa1 is required for proper mitochondrial metabolism in early development. Rahn JJ, et al. PLoS One, 2013. PMID 23516612, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66163

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular distribution of mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial fragmentation involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome fission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein complex oligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynamin-1-like protein
    NP_957216.1
    XP_005163105.1
    XP_005163106.1
    XP_005163107.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200922.1 → NP_957216.1  dynamin-1-like protein

      See identical proteins and their annotated locations for NP_957216.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055521
      UniProtKB/Swiss-Prot
      Q7SXN5
      Related
      ENSDARP00000006315.5, ENSDART00000006840.7
      Conserved Domains (4) summary
      cd08771
      Location:23 → 301
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:87 → 684
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:226 → 509
      Dynamin_M; Dynamin central region
      pfam02212
      Location:597 → 685
      GED; Dynamin GTPase effector domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      20229573..20258638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163049.3 → XP_005163106.1  dynamin-1-like protein isoform X2

      UniProtKB/TrEMBL
      A0A140LH30, A0A8M2BA29
      Related
      ENSDARP00000142560.1, ENSDART00000173434.2
      Conserved Domains (4) summary
      cd08771
      Location:23 → 301
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:87 → 708
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:226 → 509
      Dynamin_M; Dynamin central region
      pfam02212
      Location:621 → 709
      GED; Dynamin GTPase effector domain

    2. XM_005163050.3 → XP_005163107.1  dynamin-1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A8M2BA46
      Conserved Domains (4) summary
      cd08771
      Location:23 → 313
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:99 → 696
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:238 → 521
      Dynamin_M; Dynamin central region
      pfam02212
      Location:609 → 697
      GED; Dynamin GTPase effector domain

    3. XM_005163048.4 → XP_005163105.1  dynamin-1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAD6
      Conserved Domains (4) summary
      cd08771
      Location:23 → 313
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:99 → 720
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:238 → 521
      Dynamin_M; Dynamin central region
      pfam02212
      Location:633 → 721
      GED; Dynamin GTPase effector domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SXN5.1 GenPept UniProtKB/Swiss-Prot:Q7SXN5

    Gene LinkOut

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