hacl1 2-hydroxyacyl-CoA lyase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hacl1provided by ZNC
Official Full Name: 2-hydroxyacyl-CoA lyase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2058
See related: Ensembl:ENSDARG00000020529 AllianceGenome:ZFIN:ZDB-GENE-040426-2058
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: phyh2; zgc:76920; wu:fd42e11
Summary: Predicted to enable thiamine pyrophosphate binding activity. Predicted to be involved in fatty acid alpha-oxidation. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be active in peroxisome. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (20167845..20194379)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (20362026..20388560)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 2-hydroxyacyl-CoA lyase activity	IEA Inferred from Electronic Annotation more info
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables thiamine pyrophosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid alpha-oxidation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 2-hydroxyacyl-CoA lyase 1

Names: phytanoyl-CoA 2-hydroxylase 2

NP_998250.1

EC 4.1.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213085.1 → NP_998250.1 2-hydroxyacyl-CoA lyase 1

See identical proteins and their annotated locations for NP_998250.1

Status: PROVISIONAL

Source sequence(s)

BC066580

UniProtKB/TrEMBL

Q6NYI5

Related

ENSDARP00000005715.8, ENSDART00000004031.10

Conserved Domains (4) summary

cd07035
Location:8 → 160

TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins

PRK09259
Location:5 → 552

PRK09259; putative oxalyl-CoA decarboxylase; Validated

cd02004
Location:367 → 550

TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...

pfam00205
Location:193 → 322

TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain