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    pcxa pyruvate carboxylase a [ Danio rerio (zebrafish) ]

    Gene ID: 553283, updated on 17-Aug-2024

    Summary

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    Official Symbol
    pcxaprovided by ZNC
    Official Full Name
    pyruvate carboxylase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090908-3
    See related
    Ensembl:ENSDARG00000098766 AllianceGenome:ZFIN:ZDB-GENE-090908-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pcl; PYCa; zgc:123047
    Summary
    Predicted to enable pyruvate carboxylase activity. Acts upstream of or within habituation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (26733345..26966059)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (26696650..26929364)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 3 member 2b Neighboring gene calmodulin 3b (phosphorylase kinase, delta) Neighboring gene uncharacterized LOC101883097 Neighboring gene uncharacterized LOC101883049 Neighboring gene leucine rich repeat and fibronectin type III domain containing 4a Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14Ba Neighboring gene FKBP prolyl isomerase 2 Neighboring gene solute carrier family 8 member 4a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A genome-wide screen identifies PAPP-AA-mediated IGFR signaling as a novel regulator of habituation learning. Wolman MA, et al. Neuron, 2015 Mar 18. PMID 25754827, Free PMC Article
    2. Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan. Liu Y, et al. Front Genet, 2020. PMID 32849832, Free PMC Article
    3. Global protein expression profiling of zebrafish organs based on in vivo incorporation of stable isotopes. Nolte H, et al. J Proteome Res, 2014 Apr 4. PMID 24611545
    4. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123047

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within habituation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pyruvate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate carboxylase a
    Names
    pyruvate carboxylase, like
    NP_001315285.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328356.1 → NP_001315285.1  pyruvate carboxylase a

      Status: VALIDATED

      Source sequence(s)
      BX324223, BX465183, BX465841, BX530073
      UniProtKB/TrEMBL
      A0A0R4IFJ4, A0A8M1P3R3
      Related
      ENSDARP00000132084.1, ENSDART00000168379.2

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      26733345..26966059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037670.1: Suppressed sequence

      Description
      NM_001037670.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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