cbx2 chromobox homolog 2 (Drosophila Pc class) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cbx2provided by ZNC
Official Full Name: chromobox homolog 2 (Drosophila Pc class)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5502
See related: Ensembl:ENSDARG00000044938 AllianceGenome:ZFIN:ZDB-GENE-030131-5502
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pc1; wu:fd20e09; zgc:103563
Summary: Predicted to enable methylated histone binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Predicted to be active in heterochromatin. Is expressed in several structures, including digestive system; heart; nervous system; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in 46,XY sex reversal 5. Orthologous to human CBX2 (chromobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (10152133..10164754)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (10182822..10195443)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PRC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PRC1 complex	IEA Inferred from Electronic Annotation more info
part_of heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chromobox protein homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.