csnk1a1 casein kinase 1, alpha 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: csnk1a1provided by ZNC
Official Full Name: casein kinase 1, alpha 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-020419-19
See related: Ensembl:ENSDARG00000052674 AllianceGenome:ZFIN:ZDB-GENE-020419-19
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ck1alpha; sb:eu866; CHUNP6894; zgc:92158; wu:fb65a02; wu:fi30h04; wu:fj19c11
Summary: Enables protein serine/threonine kinase activity. Acts upstream of or within heart development and peptidyl-serine phosphorylation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; head; otic vesicle; pectoral fin; and solid lens vesicle. Orthologous to several human genes including CSNK1A1 (casein kinase 1 alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (38761826..38783612, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (38422669..38443316, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, we report that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by I-kappa-B-kinase-beta and casein kinase-1alpha and consequently degraded by the proteasome.
Title: Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2.
The phosphorylation of p53 by CK1 is an isoform-specific reaction to the K(221)RQK(224) loop.
Title: Isoform specific phosphorylation of p53 by protein kinase CK1.
data provide a molecular insight into the structural features that underlie the site specificity of CK1a
Title: Generation of protein kinase Ck1alpha mutants which discriminate between canonical and non-canonical substrates.

Submit: New GeneRIF Correction

General gene information

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Markers

fj19c11.x1 (e-PCR)
- UniSTS:198703

fc74d07.y1 (e-PCR)
- UniSTS:194424

fb65a02 (e-PCR)
- UniSTS:189063

fb06f03.x1 (e-PCR)
- UniSTS:202715

AW174977 (e-PCR)
- UniSTS:205792

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IC Inferred by Curator more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, alcohol group as acceptor	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
NOT located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: casein kinase I

NP_694483.1

EC 2.7.1.-

XP_009289361.1

EC 2.7.1.-

XP_009289362.1

EC 2.7.1.-

XP_009289364.1

EC 2.7.1.-

XP_009289365.1

EC 2.7.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.