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    spg7 SPG7 matrix AAA peptidase subunit, paraplegin [ Danio rerio (zebrafish) ]

    Gene ID: 794740, updated on 17-Aug-2024

    Summary

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    Official Symbol
    spg7provided by ZNC
    Official Full Name
    SPG7 matrix AAA peptidase subunit, parapleginprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5391
    See related
    Ensembl:ENSDARG00000068187 AllianceGenome:ZFIN:ZDB-GENE-030131-5391
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd15f08; wu:fd15f08
    Summary
    Predicted to enable ATP binding activity; peptidase activity; and zinc ion binding activity. Predicted to be involved in mitochondrial protein processing and protein-containing complex assembly. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (56152257..56180714, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (55850650..55879297, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase family member 3 Neighboring gene cadherin 15, type 1, M-cadherin (myotubule) Neighboring gene ankyrin repeat domain 11 Neighboring gene uncharacterized LOC101882977 Neighboring gene uncharacterized LOC100536797

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Early embryonic exposure to polychlorinated biphenyls disrupts heat-shock protein 70 cognate expression in zebrafish. Kreiling JA, et al. J Toxicol Environ Health A, 2007 Jun. PMID 17497411
    2. Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes. England SJ, et al. Front Cell Dev Biol, 2017. PMID 28271061, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of m-AAA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    paraplegin
    Names
    spastic paraplegia 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      56152257..56180714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001923083.6 → XP_001923118.1  paraplegin isoform X1

      UniProtKB/TrEMBL
      A0A8M1QHU6, E7F2S4
      Conserved Domains (4) summary
      TIGR01241
      Location:257 → 738
      FtsH_fam; ATP-dependent metalloprotease FtsH
      pfam00004
      Location:337 → 470
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam01434
      Location:552 → 736
      Peptidase_M41; Peptidase family M41
      pfam06480
      Location:136 → 233
      FtsH_ext; FtsH Extracellular

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394712.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      628295..650306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472024.1 → XP_021327699.1  paraplegin isoform X2

      UniProtKB/TrEMBL
      A0A8M9PS13
      Conserved Domains (2) summary
      pfam06480
      Location:99 → 196
      FtsH_ext; FtsH Extracellular
      cl27568
      Location:220 → 701
      TIP49; TIP49 C-terminus

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395269.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      419428..441439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474143.1 → XP_021329818.1  paraplegin isoform X3

      UniProtKB/TrEMBL
      A0A8M9PS13
      Conserved Domains (2) summary
      pfam06480
      Location:99 → 196
      FtsH_ext; FtsH Extracellular
      cl27568
      Location:220 → 701
      TIP49; TIP49 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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