cep72 centrosomal protein 72 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cep72provided by ZNC
Official Full Name: centrosomal protein 72provided by ZNC
Primary source: ZFIN:ZDB-GENE-101115-1
See related: Ensembl:ENSDARG00000105258 AllianceGenome:ZFIN:ZDB-GENE-101115-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to be involved in gamma-tubulin complex localization and spindle organization. Predicted to be located in centrosome. Orthologous to human CEP72 (centrosomal protein 72). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (52847079..52864785)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (52961054..52978952)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study proposes that Cep290 and Cep72 in centriolar satellites regulate the ciliary localization of BBS4, which in turn affects assembly and recruitment of the BBSome.
Title: The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in gamma-tubulin complex localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in spindle organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: centrosomal protein of 72 kDa

Names: centrosomal protein 72 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001319132.1 → NP_001306061.1 centrosomal protein of 72 kDa

Status: VALIDATED

Source sequence(s)

CU855947, CU929113, EH546801, EH567938, EH598638

UniProtKB/Swiss-Prot

Q501X2

UniProtKB/TrEMBL

A0A0R4IXQ3, A0A8M1P7E3

Related

ENSDARP00000139674.2, ENSDART00000163151.2

Conserved Domains (4) summary

sd00031
Location:53 → 74

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:15 → 29

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:52 → 91

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:52 → 110

LRR_8; Leucine rich repeat