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    arhgap27 Rho GTPase activating protein 27 [ Danio rerio (zebrafish) ]

    Gene ID: 564211, updated on 14-Nov-2024

    Summary

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    Official Symbol
    arhgap27provided by ZNC
    Official Full Name
    Rho GTPase activating protein 27provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3922
    See related
    Ensembl:ENSDARG00000104255 AllianceGenome:ZFIN:ZDB-GENE-030131-3922
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc59a09; wu:fc59a09
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm and plasma membrane. Is expressed in ectoderm. Orthologous to human ARHGAP27 (Rho GTPase activating protein 27). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See arhgap27 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (4971852..5046139)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (4936731..5009347)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene interferon phi 4 Neighboring gene pleckstrin homology domain containing, family M (with RUN domain) member 1 Neighboring gene small nucleolar RNA SNORA30/SNORA37 family Neighboring gene small nucleolar RNA SNORA30/SNORA37 family Neighboring gene kinesin family member 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Optogenetic control of YAP cellular localisation and function. Toh PJY, et al. EMBO Rep, 2022 Sep 5. PMID 35876586, Free PMC Article
    2. Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1. Kimelman D, et al. Elife, 2017 Dec 28. PMID 29283341, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 15; rho GTPase-activating protein 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      4971852..5046139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156026.5 → XP_005156083.1  rho GTPase-activating protein 27 isoform X1

      See identical proteins and their annotated locations for XP_005156083.1

      UniProtKB/TrEMBL
      A0A8M2B2D3
      Conserved Domains (5) summary
      cd04403
      Location:808 → 992
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:614 → 725
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:613 → 726
      PH; PH domain
      pfam00397
      Location:382 → 410
      WW; WW domain
      cl17036
      Location:22 → 77
      SH3; Src Homology 3 domain superfamily

    2. XM_021480216.2 → XP_021335891.1  rho GTPase-activating protein 27 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QIZ3
      Conserved Domains (5) summary
      cd04403
      Location:784 → 968
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:590 → 701
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:382 → 410
      WW; WW domain
      cl17036
      Location:22 → 77
      SH3; Src Homology 3 domain superfamily
      cl28033
      Location:144 → 525
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    3. XM_005156029.5 → XP_005156086.1  rho GTPase-activating protein 27 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B2N4, E7FCI7
      Related
      ENSDARP00000132429.1, ENSDART00000161076.2
      Conserved Domains (5) summary
      cd04403
      Location:779 → 963
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:585 → 696
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:584 → 697
      PH; PH domain
      pfam00397
      Location:382 → 410
      WW; WW domain
      cl17036
      Location:22 → 77
      SH3; Src Homology 3 domain superfamily

    4. XM_005156027.5 → XP_005156084.1  rho GTPase-activating protein 27 isoform X1

      See identical proteins and their annotated locations for XP_005156084.1

      UniProtKB/TrEMBL
      A0A8M2B2D3
      Conserved Domains (5) summary
      cd04403
      Location:808 → 992
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:614 → 725
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:613 → 726
      PH; PH domain
      pfam00397
      Location:382 → 410
      WW; WW domain
      cl17036
      Location:22 → 77
      SH3; Src Homology 3 domain superfamily

    5. XM_009306431.4 → XP_009304706.1  rho GTPase-activating protein 15 isoform X4

      UniProtKB/TrEMBL
      A0A8M3B778
      Conserved Domains (4) summary
      cd04403
      Location:589 → 773
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:395 → 506
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:394 → 507
      PH; PH domain
      pfam00397
      Location:163 → 191
      WW; WW domain

    6. XM_002663903.7 → XP_002663949.3  rho GTPase-activating protein 15 isoform X5

      UniProtKB/TrEMBL
      A0A8M1RHJ9
      Conserved Domains (4) summary
      cd04403
      Location:572 → 756
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:378 → 489
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:377 → 490
      PH; PH domain
      pfam00397
      Location:146 → 174
      WW; WW domain
    Nucleotide Protein
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