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    eif2ak3 eukaryotic translation initiation factor 2-alpha kinase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 559564, updated on 17-Aug-2024

    Summary

    Official Symbol
    eif2ak3provided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 2-alpha kinase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050414-2
    See related
    Ensembl:ENSDARG00000062139 AllianceGenome:ZFIN:ZDB-GENE-050414-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    PEK; zgc:152949
    Summary
    Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity. Acts upstream of or within response to endoplasmic reticulum stress and response to hypoxia. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    Location:
    chromosome: 13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (13945148..14004550)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (13814162..13873558)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 member 11 Neighboring gene ribose 5-phosphate isomerase A (ribose 5-phosphate epimerase) Neighboring gene uncharacterized LOC101884819 Neighboring gene attractin Neighboring gene GDNF family receptor alpha 4a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Clone Names

    • MGC152949

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 2-alpha kinase 3
    Names
    PERK
    XP_005156642.2
    XP_021336441.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      13945148..14004550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480766.1XP_021336441.1  eukaryotic translation initiation factor 2-alpha kinase 3

      UniProtKB/TrEMBL
      A0A8M9QK34, B8JI14
      Conserved Domains (2) summary
      cd09768
      Location:100437
      Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
      cd14048
      Location:6061063
      STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394873.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      179211..234501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156585.4XP_005156642.2  eukaryotic translation initiation factor 2-alpha kinase 3

      UniProtKB/TrEMBL
      A0A8M2B3B8
      Conserved Domains (2) summary
      cd09768
      Location:100437
      Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
      cd14048
      Location:6061063
      STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077149.2: Suppressed sequence

      Description
      NM_001077149.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.