fabp10a fatty acid binding protein 10a, liver basic [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fabp10aprovided by ZNC
Official Full Name: fatty acid binding protein 10a, liver basicprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020318-1
See related: Ensembl:ENSDARG00000038439 AllianceGenome:ZFIN:ZDB-GENE-020318-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Lfabp; L-FABP; fabp10; Lb-FABP; z-L-BABP; Zf-FABP10; zgc:92741; zgc:103719
Summary: Enables bile acid binding activity. Predicted to be involved in fatty acid transport. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including eye; female organism; heart; liver; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (52512025..52516923)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (52626282..52631180)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

describe the regulation at the duplicated zebrafish fabp7a/fabp7b, fabp10a/fabp10b and fabp11a/fabp11b gene promoters.
Title: Differential regulation of the duplicated fabp7, fabp10 and fabp11 genes of zebrafish by peroxisome proliferator activated receptors.
The differential tissue distribution of transcripts for the duplicated fabp10 genes suggests considerable divergence of their cis-acting regulatory elements since their duplication.
Title: Differential tissue-specific distribution of transcripts for the duplicated fatty acid-binding protein 10 (fabp10) genes in embryos, larvae and adult zebrafish (Danio rerio).
The structure of the holoprotein is also compared with that of the liver BABP from the same species and those of other I-BABPs determined by NMR.
Title: The X-ray structure of zebrafish (Danio rerio) ileal bile acid-binding protein reveals the presence of binding sites on the surface of the protein molecule.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables bile acid binding	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fatty acid-binding protein 10-A, liver basic

Names: L-BABP; fatty acid binding protein 10, liver basic; fatty acid-binding protein 10; fatty acid-binding protein, liver; liver bile acid-binding protein; liver-type FABP; liver-type fatty acid binding protein; small cytosolic protein involved in lipid transport and metabolism; zf-Lb-FABP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152960.1 → NP_694492.1 fatty acid-binding protein 10-A, liver basic

See identical proteins and their annotated locations for NP_694492.1

Status: PROVISIONAL

Source sequence(s)

AF254642

UniProtKB/Swiss-Prot

Q8JHE8, Q9I8L5

UniProtKB/TrEMBL

B2GQZ3

Related

ENSDARP00000056094.5, ENSDART00000056095.6

Conserved Domains (1) summary

cd19447
Location:2 → 125

L-BABP-like; liver bile acid-binding protein and similar proteins