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    abi1a abl-interactor 1a [ Danio rerio (zebrafish) ]

    Gene ID: 393711, updated on 10-Sep-2024

    Summary

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    Official Symbol
    abi1aprovided by ZNC
    Official Full Name
    abl-interactor 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1701
    See related
    Ensembl:ENSDARG00000010155 AllianceGenome:ZFIN:ZDB-GENE-040426-1701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    abi1; zgc:73174; wu:fc66g09; wu:fk56a10
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to act upstream of or within actin polymerization or depolymerization. Predicted to be located in cell junction; cytoskeleton; and filopodium. Predicted to be active in lamellipodium. Orthologous to human ABI1 (abl interactor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (5935411..6011527)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (5906083..5981999)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 64 Neighboring gene acyl-CoA binding domain containing 5a Neighboring gene tripartite motif-containing protein 16-like Neighboring gene prenyl (decaprenyl) diphosphate synthase, subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. Edwards JJ, et al. JACC Basic Transl Sci, 2020 Apr. PMID 32368696, Free PMC Article
    2. Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish. Seiler C, et al. PLoS One, 2015. PMID 26161877, Free PMC Article
    3. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
    4. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC73174

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SH3 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin-based cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    abl interactor 1; abl interactor 1a
    Names
    abl-interactor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328427.1 → NP_001315356.1  abl interactor 1a

      Status: VALIDATED

      Source sequence(s)
      CR385039
      UniProtKB/TrEMBL
      A0A8M1PA08, F1R187
      Related
      ENSDARP00000116601.1, ENSDART00000131768.2
      Conserved Domains (3) summary
      cd11971
      Location:425 → 483
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 165
      Abi_HHR; Abl-interactor HHR
      cl23725
      Location:405 → 435
      Glyco_hydro_1; Glycosyl hydrolase family 1

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      5935411..6011527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297227.3 → XP_009295502.1  abl interactor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AND6
      Conserved Domains (3) summary
      cd11971
      Location:464 → 522
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 162
      Abi_HHR; Abl-interactor HHR
      cl23725
      Location:444 → 474
      Glyco_hydro_1; Glycosyl hydrolase family 1

    2. XM_009297229.3 → XP_009295504.1  abl interactor 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AP19
      Conserved Domains (3) summary
      cd11971
      Location:370 → 428
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 162
      Abi_HHR; Abl-interactor HHR
      cl23725
      Location:350 → 380
      Glyco_hydro_1; Glycosyl hydrolase family 1

    3. XM_005162489.4 → XP_005162546.1  abl interactor 1 isoform X3

      UniProtKB/TrEMBL
      A0A2R8QEN6, A0A8M2B9D1
      Conserved Domains (3) summary
      cd11971
      Location:430 → 488
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 162
      Abi_HHR; Abl-interactor HHR
      cl23725
      Location:410 → 440
      Glyco_hydro_1; Glycosyl hydrolase family 1

    4. XM_009297228.3 → XP_009295503.1  abl interactor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B6H8
      Conserved Domains (3) summary
      cd11971
      Location:459 → 517
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 165
      Abi_HHR; Abl-interactor HHR
      cl23725
      Location:439 → 469
      Glyco_hydro_1; Glycosyl hydrolase family 1

    5. XM_005162496.4 → XP_005162553.1  abl interactor 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M2B9B3
      Conserved Domains (3) summary
      cd11971
      Location:365 → 423
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93 → 165
      Abi_HHR; Abl-interactor HHR
      cl23725
      Location:345 → 375
      Glyco_hydro_1; Glycosyl hydrolase family 1

    6. XM_005162498.4 → XP_005162555.1  abl interactor 1 isoform X6

      UniProtKB/TrEMBL
      A0A2R8Q1F3, A0A8M2B9J6
      Conserved Domains (3) summary
      pfam07815
      Location:93 → 162
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:336 → 394
      SH3; Src Homology 3 domain superfamily
      cl23725
      Location:316 → 346
      Glyco_hydro_1; Glycosyl hydrolase family 1

    7. XM_005162499.4 → XP_005162556.1  abl interactor 1 isoform X7

      UniProtKB/TrEMBL
      A0A8M2B9D2
      Conserved Domains (3) summary
      pfam07815
      Location:93 → 165
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:331 → 389
      SH3; Src Homology 3 domain superfamily
      cl23725
      Location:311 → 341
      Glyco_hydro_1; Glycosyl hydrolase family 1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_200738.1: Suppressed sequence

      Description
      NM_200738.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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