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    unc119b unc-119 lipid binding chaperone B [ Danio rerio (zebrafish) ]

    Gene ID: 338230, updated on 2-Nov-2024

    Summary

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    Official Symbol
    unc119bprovided by ZNC
    Official Full Name
    unc-119 lipid binding chaperone Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030219-130
    See related
    Ensembl:ENSDARG00000009629 AllianceGenome:ZFIN:ZDB-GENE-030219-130
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    unc119.1; zfUnc119b; id:ibd2212; wu:fc47b02; zgc:111863
    Summary
    Predicted to enable lipid binding activity. Involved in cilium assembly. Acts upstream of or within Kupffer's vesicle development and nervous system development. Predicted to be located in cell projection. Predicted to be active in cilium. Is expressed in several structures, including mesoderm; nervous system; neural plate; pronephric duct; and spinal cord neural tube. Orthologous to human UNC119B (unc-119 lipid binding chaperone B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See unc119b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (39850374..39859791, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (39818321..39825885, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100000633 Neighboring gene zgc:174931 Neighboring gene malectin Neighboring gene calcium binding protein 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. unc-119 homolog required for normal development of the zebrafish nervous system. Manning AG, et al. Genesis, 2004 Dec. PMID 15593328
    2. Knockdown of unc119c results in visual impairment and early-onset retinal dystrophy in zebrafish. Rainy N, et al. Biochem Biophys Res Commun, 2016 May 13. PMID 27079236
    3. Evolution and expression of the zebrafish unc119 paralogues indicates a conserved role in cilia. Jean F, et al. Gene Expr Patterns, 2019 Sep. PMID 31055152
    4. An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. Wright KJ, et al. Genes Dev, 2011 Nov 15. PMID 22085962, Free PMC Article
    5. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111863

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Kupffer's vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipoprotein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein unc-119 homolog B
    Names
    Unc119c
    protein unc-119 homolog 1
    unc-119 homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212787.1 → NP_997952.1  protein unc-119 homolog B

      See identical proteins and their annotated locations for NP_997952.1

      Status: PROVISIONAL

      Source sequence(s)
      AF387342
      UniProtKB/Swiss-Prot
      A9C3N9, B3DG53, Q502S5, Q90Z08
      Related
      ENSDARP00000011779.7, ENSDART00000019907.9
      Conserved Domains (1) summary
      pfam05351
      Location:81 → 239
      GMP_PDE_delta; GMP-PDE, delta subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      39850374..39859791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478199.2 → XP_021333874.1  protein unc-119 homolog B isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q9J8
      Conserved Domains (1) summary
      pfam05351
      Location:128 → 257
      GMP_PDE_delta; GMP-PDE, delta subunit

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077749.1: Suppressed sequence

      Description
      NM_001077749.1: This RefSeq was permanently suppressed because it is based on chimeric sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90Z08.2 GenPept UniProtKB/Swiss-Prot:Q90Z08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.