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    SPATA24 spermatogenesis associated 24 [ Homo sapiens (human) ]

    Gene ID: 202051, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SPATA24provided by HGNC
    Official Full Name
    spermatogenesis associated 24provided by HGNC
    Primary source
    HGNC:HGNC:27322
    See related
    Ensembl:ENSG00000170469 AllianceGenome:HGNC:27322
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T6441; CCDC161
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 10.5), prostate (RPKM 2.2) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SPATA24 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (139392500..139404089, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (139922301..139929892, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138732456..138739778, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein interacting protein 2 Neighboring gene solute carrier family 23 member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138716531-138717471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138723739-138724286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138724287-138724834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138724835-138725382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16409 Neighboring gene Sharpr-MPRA regulatory region 996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16411 Neighboring gene marginal zone B and B1 cell specific protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23230 Neighboring gene proline rich basic protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138739142-138739715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138739716-138740288 Neighboring gene DnaJ heat shock protein family (Hsp40) member C18 Neighboring gene uncharacterized LOC124901082 Neighboring gene NANOG hESC enhancer GRCh37_chr5:138755520-138756025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:138773284-138773784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16413 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:138775085-138775584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23232 Neighboring gene RNA, U5B small nuclear 4, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in male germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    spermatogenesis-associated protein 24
    Names
    coiled-coil domain containing 161
    testis protein T6441 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194296.2 → NP_919272.1  spermatogenesis-associated protein 24

      See identical proteins and their annotated locations for NP_919272.1

      Status: VALIDATED

      Source sequence(s)
      AA399058, AC135457, BC040037, BM785501
      Consensus CDS
      CCDS47274.1
      UniProtKB/Swiss-Prot
      Q86W54
      Related
      ENSP00000414920.2, ENST00000450845.7
      Conserved Domains (1) summary
      pfam15175
      Location:25 → 191
      SPATA24; Spermatogenesis-associated protein 24

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      139392500..139404089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271916.5 → XP_005271973.1  spermatogenesis-associated protein 24 isoform X1

      Conserved Domains (3) summary
      pfam13863
      Location:50 → 161
      DUF4200; Domain of unknown function (DUF4200)
      pfam15175
      Location:25 → 162
      SPATA24; Spermatogenesis-associated protein 24
      pfam16006
      Location:130 → 220
      NUSAP; Nucleolar and spindle-associated protein

    2. XM_011543253.3 → XP_011541555.1  spermatogenesis-associated protein 24 isoform X2

      See identical proteins and their annotated locations for XP_011541555.1

      Conserved Domains (3) summary
      pfam13863
      Location:11 → 122
      DUF4200; Domain of unknown function (DUF4200)
      pfam15175
      Location:1 → 123
      SPATA24; Spermatogenesis-associated protein 24
      pfam16006
      Location:91 → 181
      NUSAP; Nucleolar and spindle-associated protein

    3. XM_011543252.3 → XP_011541554.1  spermatogenesis-associated protein 24 isoform X2

      See identical proteins and their annotated locations for XP_011541554.1

      Conserved Domains (3) summary
      pfam13863
      Location:11 → 122
      DUF4200; Domain of unknown function (DUF4200)
      pfam15175
      Location:1 → 123
      SPATA24; Spermatogenesis-associated protein 24
      pfam16006
      Location:91 → 181
      NUSAP; Nucleolar and spindle-associated protein

    4. XM_011543254.3 → XP_011541556.1  spermatogenesis-associated protein 24 isoform X3

      UniProtKB/TrEMBL
      H0Y992
      Conserved Domains (1) summary
      pfam15175
      Location:25 → 134
      SPATA24; Spermatogenesis-associated protein 24

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      139922301..139929892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351971.1 → XP_054207946.1  spermatogenesis-associated protein 24 isoform X1

    2. XM_054351972.1 → XP_054207947.1  spermatogenesis-associated protein 24 isoform X2

    3. XM_054351973.1 → XP_054207948.1  spermatogenesis-associated protein 24 isoform X2

    4. XM_054351974.1 → XP_054207949.1  spermatogenesis-associated protein 24 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86W54.2 GenPept UniProtKB/Swiss-Prot:Q86W54

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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