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    Meis1 Meis homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 17268, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Meis1provided by MGI
    Official Full Name
    Meis homeobox 1provided by MGI
    Primary source
    MGI:MGI:104717
    See related
    Ensembl:ENSMUSG00000020160 AllianceGenome:MGI:104717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Evi8; C530044H18Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of myeloid cell differentiation and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including angiogenesis; hemopoiesis; and lens morphogenesis in camera-type eye. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study restless legs syndrome. Orthologous to human MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 25.6), CNS E11.5 (RPKM 9.3) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Meis1 in Genome Data Viewer
    Location:
    11 A3.1; 11 11.11 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (18830428..18968992, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (18880428..19019651, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31674 Neighboring gene predicted gene, 23021 Neighboring gene RIKEN cDNA 8430419K02 gene Neighboring gene STARR-seq mESC enhancer starr_28733 Neighboring gene STARR-seq mESC enhancer starr_28735 Neighboring gene STARR-seq mESC enhancer starr_28736 Neighboring gene predicted gene 16141 Neighboring gene RIKEN cDNA 4933406G16 gene Neighboring gene STARR-seq mESC enhancer starr_28738 Neighboring gene STARR-seq mESC enhancer starr_28739 Neighboring gene STARR-seq mESC enhancer starr_28740 Neighboring gene predicted gene, 53669

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A knock-in mouse strain facilitates dynamic tracking and enrichment of MEIS1. Xiang P, et al. Blood Adv, 2017 Nov 14. PMID 29296870, Free PMC Article
    2. A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice. Leu CL, et al. Sleep, 2024 May 10. PMID 38314840, Free PMC Article
    3. Meis1 regulates epidermal stem cells and is required for skin tumorigenesis. Okumura K, et al. PLoS One, 2014. PMID 25013928, Free PMC Article
    4. Meis1 disrupts the genomic imprint of Dlk1 in a NUP98-HOXD13 leukemia model. Argiropoulos B, et al. Leukemia, 2010 Oct. PMID 20739957
    5. Meis1: effects on motor phenotypes and the sensorimotor system in mice. Salminen AV, et al. Dis Model Mech, 2017 Aug 1. PMID 28645892, Free PMC Article

    See all (250) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Meis1 Targets Protein Tyrosine Phosphatase Receptor J in Fibroblast to Retard Chronic Kidney Disease Progression.
      Title: Meis1 Targets Protein Tyrosine Phosphatase Receptor J in Fibroblast to Retard Chronic Kidney Disease Progression.
    2. A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice.
      Title: A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice.
    3. Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice.
      Title: Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice.
    4. A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML.
      Title: A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML.
    5. Transcription factor Meis1 act as a new regulator of ischemic arrhythmias in mice.
      Title: Transcription factor Meis1 act as a new regulator of ischemic arrhythmias in mice.
    6. Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum.
      Title: Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum.
    7. Homeobox transcription factor Meis1 is crucial to Sertoli cell mediated regulation of male fertility.
      Title: Homeobox transcription factor Meis1 is crucial to Sertoli cell mediated regulation of male fertility.
    8. Investigation of dopaminergic signalling in Meis homeobox 1 (Meis1) deficient mice as an animal model of restless legs syndrome.
      Title: Investigation of dopaminergic signalling in Meis homeobox 1 (Meis1) deficient mice as an animal model of restless legs syndrome.
    9. MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.
      Title: MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.
    10. Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors.
      Title: Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors.
    Submit: New GeneRIF Correction See all GeneRIFs (79)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell growth involved in cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hemopoiesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lens morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within megakaryocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein Meis1
    Names
    myeloid ecotropic viral integration site 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193271.1 → NP_001180200.1  homeobox protein Meis1 isoform B

      See identical proteins and their annotated locations for NP_001180200.1

      Status: VALIDATED

      Description
      Transcript Variant: : This variant (B) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant A. The resulting protein (isoform B) has a shorter and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AK140748, AL645570
      Consensus CDS
      CCDS56760.1
      UniProtKB/Swiss-Prot
      B1ARH5, Q5SVC8, Q60954, Q60955, Q8CIL0
      UniProtKB/TrEMBL
      H3BLB6
      Related
      ENSMUSP00000069277.8, ENSMUST00000068264.14
      Conserved Domains (2) summary
      pfam05920
      Location:290 → 329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108 → 192
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. NM_010789.3 → NP_034919.1  homeobox protein Meis1 isoform A

      See identical proteins and their annotated locations for NP_034919.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) encodes the longer isoform (A).
      Source sequence(s)
      AL603984, AL645570
      Consensus CDS
      CCDS24453.1
      UniProtKB/TrEMBL
      H3BLB6
      Related
      ENSMUSP00000139219.2, ENSMUST00000185131.8
      Conserved Domains (2) summary
      pfam05920
      Location:290 → 329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108 → 191
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      18830428..18968992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314312.3 → XP_017169801.1  homeobox protein Meis1 isoform X2

      UniProtKB/TrEMBL
      H3BLB6
      Conserved Domains (2) summary
      pfam05920
      Location:241 → 280
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108 → 161
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. XM_006514559.5 → XP_006514622.1  homeobox protein Meis1 isoform X1

      Conserved Domains (3) summary
      TIGR01628
      Location:277 → 408
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam05920
      Location:241 → 280
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108 → 161
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    3. XM_030245628.2 → XP_030101488.1  homeobox protein Meis1 isoform X3

      UniProtKB/TrEMBL
      Q3UJ00
      Related
      ENSMUST00000118661.8
      Conserved Domains (2) summary
      pfam05920
      Location:146 → 185
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:1 → 48
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RNA

    1. XR_003949337.2 RNA Sequence

    2. XR_001779899.3 RNA Sequence

    3. XR_001779900.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60954.1 GenPept UniProtKB/Swiss-Prot:Q60954

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools