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    Tpd52l1 tumor protein D52-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 21987, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tpd52l1provided by MGI
    Official Full Name
    tumor protein D52-like 1provided by MGI
    Primary source
    MGI:MGI:1298386
    See related
    Ensembl:ENSMUSG00000000296 AllianceGenome:MGI:1298386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D53
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in G2/M transition of mitotic cell cycle and positive regulation of signal transduction. Predicted to be located in early endosome and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in brain; limb bud; otic capsule; and temporal bone petrous part. Orthologous to human TPD52L1 (TPD52 like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 17.3), ovary adult (RPKM 8.3) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tpd52l1 in Genome Data Viewer
    Location:
    10 A4; 10 17.36 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (31208369..31321989, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (31332373..31445987, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26213 Neighboring gene STARR-positive B cell enhancer ABC_E8329 Neighboring gene HD domain containing 2 Neighboring gene SPT4B, DSIF elongation factor subunit Neighboring gene STARR-seq mESC enhancer starr_26215 Neighboring gene predicted gene, 51764 Neighboring gene ring finger protein 217 Neighboring gene STARR-seq mESC enhancer starr_26216 Neighboring gene high mobility group box 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and in situ hybridization mapping of a mouse Tpd52l1 (D53) orthologue to chromosome 10A4-B2. Byrne JA, et al. Cytogenet Cell Genet, 1998. PMID 9730602
    2. D53 is a novel endosomal SNARE-binding protein that enhances interaction of syntaxin 1 with the synaptobrevin 2 complex in vitro. Proux-Gillardeaux V, et al. Biochem J, 2003 Feb 15. PMID 12376003, Free PMC Article
    3. Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52). Byrne JA, et al. Genomics, 1996 Aug 1. PMID 8812487
    4. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. Byrne JA, et al. Oncogene, 1998 Feb 19. PMID 9484778
    5. Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia. Hoerder-Suabedissen A, et al. Proc Natl Acad Sci U S A, 2013 Feb 26. PMID 23401504, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tumor protein D53

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359364.2 → NP_001346293.1  tumor protein D53 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153729, AC153969
      Consensus CDS
      CCDS87983.1
      UniProtKB/TrEMBL
      B2RUC1
      Related
      ENSMUSP00000149177.2, ENSMUST00000213528.2
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 192
      TPD52; tumor protein D52 family

    2. NM_001359365.2 → NP_001346294.1  tumor protein D53 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153729, AC153969
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 133
      TPD52; tumor protein D52 family

    3. NM_001359366.2 → NP_001346295.1  tumor protein D53 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153729, AC153969
      Consensus CDS
      CCDS87980.1
      UniProtKB/TrEMBL
      Q3V2G6
      Related
      ENSMUSP00000149749.2, ENSMUST00000214644.2
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 129
      TPD52; tumor protein D52 family

    4. NM_001428867.1 → NP_001415796.1  tumor protein D53 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153729, AC153969
      UniProtKB/TrEMBL
      A0A1L1ST53

    5. NM_001428868.1 → NP_001415797.1  tumor protein D53 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC153729, AC153969
      UniProtKB/TrEMBL
      A0A1L1SR11

    6. NM_001428869.1 → NP_001415798.1  tumor protein D53 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC153729, AC153969

    7. NM_009413.3 → NP_033439.1  tumor protein D53 isoform 2

      See identical proteins and their annotated locations for NP_033439.1

      Status: VALIDATED

      Source sequence(s)
      AC153729, AC153969
      Consensus CDS
      CCDS35877.1
      UniProtKB/Swiss-Prot
      O54818
      Related
      ENSMUSP00000000305.6, ENSMUST00000000305.7
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 187
      TPD52; Tumour protein D52 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      31208369..31321989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245062.2 → XP_030100922.1  tumor protein D53 isoform X1

      Related
      ENSMUSP00000150184.2, ENSMUST00000213639.2
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 174
      TPD52; tumor protein D52 family

    2. XM_030245063.2 → XP_030100923.1  tumor protein D53 isoform X2

      Related
      ENSMUSP00000149266.2, ENSMUST00000215515.2
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 131
      TPD52; tumor protein D52 family

    3. XM_030245064.2 → XP_030100924.1  tumor protein D53 isoform X3

      Conserved Domains (1) summary
      pfam04201
      Location:12 → 133
      TPD52; tumor protein D52 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54818.1 GenPept UniProtKB/Swiss-Prot:O54818

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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