Rab11fip3 RAB11 family interacting protein 3 (class II) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab11fip3provided by MGI
Official Full Name: RAB11 family interacting protein 3 (class II)provided by MGI
Primary source: MGI:MGI:2444431
See related: Ensembl:ENSMUSG00000037098 AllianceGenome:MGI:2444431
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FIP3; Cart1; mKIAA0665; Rab11-FIP3; D030060O14Rik
Summary: Predicted to enable several functions, including dynein light intermediate chain binding activity; protein homodimerization activity; and small GTPase binding activity. Acts upstream of or within protein localization to cilium. Located in membrane. Is active in postsynaptic recycling endosome membrane. Is expressed in several structures, including gonad; gut; immune system; liver; and retina. Orthologous to human RAB11FIP3 (RAB11 family interacting protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 86.1), frontal lobe adult (RPKM 15.3) and 23 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17 A3.3; 17 13.05 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (26208010..26289010, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (25989036..26070077, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFN-gamma/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation.
Title: IFN-γ/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation.
FIP3 and FIP4 play overlapping but distinct roles in neuronal migration downstream of Rab11 and Arfophilin-1 during cortical layer formation.
Title: FIP4/Arfophilin-2 plays overlapping but distinct roles from FIP3/Arfophilin-1 in neuronal migration during cortical layer formation.
Results suggest that FIP3 regulates dendritic formation in the hippocampus possibly through Rab11- and Arf6-mediated endosomal trafficking
Title: Endosomal localization of FIP3/Arfophilin-1 and its involvement in dendritic formation of mouse hippocampal neurons.
CART1 might be a cytoplasmic, testis-specific derepressor of RAR [CART1, cytoplasmic adaptor for RAR and TR]
Title: A novel cytoplasmic adaptor for retinoic acid receptor (RAR) and thyroid receptor functions as a Derepressor of RAR in the absence of retinoic acid.
Fip3 and Rab11 protein complex regulates recycling endosomes targeting to the cleavage furrow during late cytokinesis.
Title: The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	ISO Inferred from Sequence Orthology more info
enables dynein light intermediate chain binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in early endosome to recycling endosome transport	IEA Inferred from Electronic Annotation more info
involved_in early endosome to recycling endosome transport	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of adiponectin secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of adiponectin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cytokinetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic cytokinetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to cilium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cilium	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to cleavage furrow	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cleavage furrow	ISO Inferred from Sequence Orthology more info
involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of early endosome to recycling endosome transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of early endosome to recycling endosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytic recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to centrosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cleavage furrow	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in recycling endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: rab11 family-interacting protein 3

Names: FIP3-Rab11; cytoplasmic adaptor for RAR and TR

NP_001156340.1

EC 2.7.4.6

NP_001156341.1

EC 2.7.4.6

NP_694780.1

EC 2.7.4.6

XP_011244664.1

EC 2.7.4.6

XP_036016358.1

EC 2.7.4.6

XP_036016359.1

EC 2.7.4.6

XP_036016360.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162868.2 → NP_001156340.1 rab11 family-interacting protein 3 isoform b

See identical proteins and their annotated locations for NP_001156340.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1, that results in a shorter protein (isoform b), compared to isoform a.

Source sequence(s)

AC140047, AC159277

Consensus CDS

CCDS50040.1

UniProtKB/Swiss-Prot

Q8CHD8, Q8JZT3

Related

ENSMUSP00000112875.2, ENSMUST00000120691.9

Conserved Domains (7) summary

cd00051
Location:500 → 557

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam09457
Location:1007 → 1047

RBD-FIP; FIP domain

pfam05700
Location:770 → 880

BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)

pfam07926
Location:831 → 979

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam13499
Location:501 → 557

EF-hand_7; EF-hand domain pair

pfam14077
Location:938 → 981

WD40_alt; Alternative WD40 repeat motif

cl00143
Location:831 → 933

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
NM_001162869.2 → NP_001156341.1 rab11 family-interacting protein 3 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC140047, AC159277

Consensus CDS

CCDS50041.1

UniProtKB/Swiss-Prot

Q8CHD8

Related

ENSMUSP00000113521.2, ENSMUST00000122103.9

Conserved Domains (7) summary

cd00051
Location:500 → 557

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam09457
Location:1052 → 1092

RBD-FIP; FIP domain

pfam05700
Location:815 → 925

BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)

pfam07926
Location:876 → 1024

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam13499
Location:501 → 557

EF-hand_7; EF-hand domain pair

pfam14077
Location:983 → 1026

WD40_alt; Alternative WD40 repeat motif

cl00143
Location:876 → 978

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
NM_153140.2 → NP_694780.1 rab11 family-interacting protein 3 isoform c

See identical proteins and their annotated locations for NP_694780.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has a distinct 5' UTR and lacks many exons of the 5' coding region, compared to variant 1, that results in a protein (isoform c) that starts from an internal methionine, compared to isoform a.

Source sequence(s)

AK083658, AK085516, BE853781, BM114891, CB840427, CF170100, CF747684

Consensus CDS

CCDS50039.1

UniProtKB/Swiss-Prot

Q8CHD8

Related

ENSMUSP00000113048.2, ENSMUST00000118828.8

Conserved Domains (3) summary

pfam09457
Location:404 → 444

RBD-FIP; FIP domain

pfam05700
Location:167 → 277

BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)

cl19219
Location:251 → 330

DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

26208010..26289010 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160467.1 → XP_036016360.1 rab11 family-interacting protein 3 isoform X3

Conserved Domains (3) summary

PTZ00449
Location:12 → 331

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

COG1196
Location:796 → 1059

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam13499
Location:500 → 557

EF-hand_7; EF-hand domain pair
XM_036160466.1 → XP_036016359.1 rab11 family-interacting protein 3 isoform X2

Conserved Domains (3) summary

PTZ00449
Location:12 → 331

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

COG1196
Location:808 → 1071

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam13499
Location:500 → 557

EF-hand_7; EF-hand domain pair
XM_036160465.1 → XP_036016358.1 rab11 family-interacting protein 3 isoform X1

Conserved Domains (3) summary

PTZ00449
Location:12 → 331

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

COG1196
Location:853 → 1116

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam13499
Location:500 → 557

EF-hand_7; EF-hand domain pair
XM_011246362.4 → XP_011244664.1 rab11 family-interacting protein 3 isoform X4

Conserved Domains (2) summary

PTZ00449
Location:12 → 331

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

pfam13499
Location:500 → 557

EF-hand_7; EF-hand domain pair