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    plcg2 phospholipase C, gamma 2 [ Danio rerio (zebrafish) ]

    Gene ID: 561747, updated on 2-Nov-2024

    Summary

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    Official Symbol
    plcg2provided by ZNC
    Official Full Name
    phospholipase C, gamma 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9532
    See related
    Ensembl:ENSDARG00000068763 AllianceGenome:ZFIN:ZDB-GENE-030131-9532
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj85b03; sb:eu1064; wu:fj85b03; zgc:152893; si:ch211-260p9.2
    Summary
    Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in phospholipid catabolic process. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (phospholipase C gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See plcg2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (13248956..13293642)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (13280444..13325130)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene coactosin-like F-actin binding protein 1 Neighboring gene MTOR associated protein, eak-7 homolog Neighboring gene si:ch211-260p9.3 Neighboring gene c-Maf inducing protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Candidate risk genes for bipolar disorder are highly conserved during evolution and highly interconnected. Franklin C, et al. Bipolar Disord, 2021 Jun. PMID 32959503
    2. Transcriptional profiling of angiogenesis activities of calycosin in zebrafish. Li S, et al. Mol Biosyst, 2011 Nov. PMID 21909574
    3. The Presence or Absence of Intestinal Microbiota Affects Lipid Deposition and Related Genes Expression in Zebrafish (Danio rerio). Sheng Y, et al. Front Microbiol, 2018. PMID 29896183, Free PMC Article
    4. Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Monteiro R, et al. Dev Cell, 2016 Aug 22. PMID 27499523, Free PMC Article
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    NP_001038433.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044968.1 → NP_001038433.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

      Status: PROVISIONAL

      Source sequence(s)
      BX511124
      UniProtKB/TrEMBL
      A0A8M1N9W3, Q1LWV8
      Related
      ENSDARP00000075155.4, ENSDART00000080709.6
      Conserved Domains (8) summary
      cd00275
      Location:1044 → 1169
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08628
      Location:307 → 442
      PI-PLCc_gamma2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma2
      cd09932
      Location:631 → 734
      SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
      cd10341
      Location:516 → 617
      SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
      cd11969
      Location:762 → 816
      SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
      cd13362
      Location:22 → 139
      PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
      cl14615
      Location:892 → 1017
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:826 → 893
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      13248956..13293642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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