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    Rasgef1a RasGEF domain family, member 1A [ Mus musculus (house mouse) ]

    Gene ID: 70727, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rasgef1aprovided by MGI
    Official Full Name
    RasGEF domain family, member 1Aprovided by MGI
    Primary source
    MGI:MGI:1917977
    See related
    Ensembl:ENSMUSG00000030134 AllianceGenome:MGI:1917977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330404M18Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction; cell migration; and positive regulation of Ras protein signal transduction. Predicted to be active in plasma membrane. Is expressed in amygdala; olfactory epithelium; telencephalon mantle layer; and vomeronasal organ. Orthologous to human RASGEF1A (RasGEF domain family member 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 25.3), cortex adult (RPKM 24.6) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rasgef1a in Genome Data Viewer
    Location:
    6 F1; 6 55.85 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (117988466..118068507)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118011505..118091546)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17129 Neighboring gene FXYD domain-containing ion transport regulator 4 Neighboring gene STARR-seq mESC enhancer starr_17131 Neighboring gene predicted gene, 38884 Neighboring gene Lasp1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17132 Neighboring gene STARR-seq mESC enhancer starr_17134 Neighboring gene microRNA 7044 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene predicted gene, 23908 Neighboring gene STARR-positive B cell enhancer ABC_E6475 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:118117270-118117379 Neighboring gene STARR-positive B cell enhancer ABC_E2800 Neighboring gene ret proto-oncogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Wang N, et al. Neuron, 2022 Oct 19. PMID 36265442, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-GEF domain-containing family member 1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316749.2 → NP_001303678.1  ras-GEF domain-containing family member 1A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 3. Variants 2 and 4 both encode the same isoform (2).
      Source sequence(s)
      AC135861
      Consensus CDS
      CCDS85141.1
      UniProtKB/TrEMBL
      A6H650, B7ZNG9, E9Q1N6
      Related
      ENSMUSP00000132244.3, ENSMUST00000164960.4
      Conserved Domains (2) summary
      cd06224
      Location:49 → 176
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:218 → 410
      RasGEF; RasGEF domain

    2. NM_001362103.1 → NP_001349032.1  ras-GEF domain-containing family member 1A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AC135861
      Consensus CDS
      CCDS90110.1
      UniProtKB/TrEMBL
      A0A0N4SVR5, B7ZNG9
      Related
      ENSMUSP00000145214.2, ENSMUST00000203804.3
      Conserved Domains (2) summary
      cd06224
      Location:57 → 163
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:235 → 427
      RasGEF; RasGEF domain

    3. NM_001362104.1 → NP_001349033.1  ras-GEF domain-containing family member 1A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 3. Variants 2 and 4 both encode the same isoform (2).
      Source sequence(s)
      AC135861
      Consensus CDS
      CCDS85141.1
      UniProtKB/TrEMBL
      A6H650, B7ZNG9, E9Q1N6
      Conserved Domains (2) summary
      cd06224
      Location:49 → 176
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:218 → 410
      RasGEF; RasGEF domain

    4. NM_001362105.1 → NP_001349034.1  ras-GEF domain-containing family member 1A isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (4) has a longer and distinct N-terminus and lacks an alternate internal segment compared to isoform 3.
      Source sequence(s)
      AC135861
      UniProtKB/TrEMBL
      B7ZNG9
      Conserved Domains (2) summary
      cd06224
      Location:60 → 187
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:229 → 421
      RasGEF; RasGEF domain

    5. NM_027526.1 → NP_081802.1  ras-GEF domain-containing family member 1A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
      Source sequence(s)
      AK018120, AK158756, BY120855, BY256830
      Consensus CDS
      CCDS51883.1
      UniProtKB/TrEMBL
      A0A0N4SVF2, B7ZNG9
      Related
      ENSMUSP00000145077.2, ENSMUST00000203482.2
      Conserved Domains (2) summary
      cd06224
      Location:57 → 184
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:222 → 470
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      117988466..118068507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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