Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2b9provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily b, polypeptide 9provided by MGI
Primary source: MGI:MGI:88600
See related: Ensembl:ENSMUSG00000040660 AllianceGenome:MGI:88600
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cyp2b
Summary: Predicted to enable heme binding activity and monooxygenase activity. Involved in response to stilbenoid. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward liver adult (RPKM 171.9) See more
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Genomic context

Location:: 7 A3; 7 14.11 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (25872775..25910086)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (26173350..26210661)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multiple microRNAs participated in the regulation of Cyp2b9 expression.
Title: Role of multiple microRNAs in the sexually dimorphic expression of Cyp2b9 in mouse liver.
Report lentiviral-mediated RNAi knockdown of multiple mouse Cyp2b enzymes.
Title: Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.
Miroestrol and deoxymiroestrol significantly up-regulated CYP2B9 while suppressing CYP1A2 at both transcriptional and enzymatic levels.
Title: Bimodal action of miroestrol and deoxymiroestrol, phytoestrogens from Pueraria candollei var. mirifica, on hepatic CYP2B9 and CYP1A2 expressions and antilipid peroxidation in mice.
This study determined the regulatory region of the mouse Cyp2b9 gene and showed that FoxA2 is a predictably responsible nuclear factor in the female-predominant expression of the gene.
Title: Forkhead box A2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene.
During the maturation stage, CYP2B10 was expressed in both sexes, whereas CYP2B9 was diminished markedly in the males
Title: Sexual dimorphic expression of mouse hepatic CYP2B: alterations during development or after hypophysectomy.
These observations suggest that the sexually dimorphic expression of CYP2B9 is partly due to suppression by the masculine plasma GH profile and by glucocorticoid hormones.
Title: Suppression of female-specific murine Cyp2b9 gene expression by growth or glucocorticoid hormones.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491304

Cyp2b10 (e-PCR), detects polymorphism
- UniSTS:462990

AI256109 (e-PCR)
- UniSTS:208095

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables anandamide 11,12 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables anandamide 14,15 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables anandamide 8,9 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables estrogen 2-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables testosterone 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables testosterone 16-beta-hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular ketone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2B9

Names: 16alphaoh-a; CYPIIB9; cytochrome P450 clone PF26; cytochrome P450, 2b9, phenobarbitol inducible, type a; cytochrome P450-16-alpha; phenobarbitol inducible, type a; testosterone 16-alpha hydroxylase

NP_034130.1

EC 1.14.14.1

XP_011248733.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.