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    SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone [ Homo sapiens (human) ]

    Gene ID: 10910, updated on 5-May-2024

    Summary

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    Official Symbol
    SUGT1provided by HGNC
    Official Full Name
    SGT1 homolog, MIS12 kinetochore complex assembly cochaperoneprovided by HGNC
    Primary source
    HGNC:HGNC:16987
    See related
    Ensembl:ENSG00000165416 MIM:604098; AllianceGenome:HGNC:16987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGT1
    Summary
    This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in brain (RPKM 4.1), testis (RPKM 3.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SUGT1 in Genome Data Viewer
    Location:
    13q14.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (52652836..52700909)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (51868272..51916337)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (53226971..53275044)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7793 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7794 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:53226721-53227222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7795 Neighboring gene SUGT1 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr13:53286351-53286901 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:53294479-53295260 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:53295261-53296041 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:53296347-53296555 Neighboring gene chondromodulin Neighboring gene NANOG hESC enhancer GRCh37_chr13:53311525-53312026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:53353321-53353820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:53361012-53361528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:53361529-53362044 Neighboring gene microRNA 759

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Hsp90 and its co-chaperone, Sgt1, as autoantigens in dilated cardiomyopathy. Kapustian LL, et al. Heart Vessels, 2013 Jan. PMID 22286152
    2. Nuclear translocation of Sgt1 depends on its phosphorylation state. Prus W, et al. Int J Biochem Cell Biol, 2011 Dec. PMID 21864708
    3. Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance. Iwatsuki M, et al. Int J Oncol, 2010 Mar. PMID 20126976
    4. Sgt1 plays polo during cell division. Martins T, et al. Cell Cycle, 2009 Apr 15. PMID 19305138
    5. Sgt1 has co-chaperone properties and is up-regulated by heat shock. Zabka M, et al. Biochem Biophys Res Commun, 2008 May 23. PMID 18358234

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends.
      Title: SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends.
    2. REVIEW: cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1
      Title: Current view on cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1.
    3. the SGT1-HSP90 complex contributes to the E3 ligase activity of the CUL4A complex that is necessary for CENP-A ubiquitylation and CENP-A deposition at the centromere.
      Title: SGT1-HSP90 complex is required for CENP-A deposition at centromeres.
    4. Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41-mediated SGT1 degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 = ring finger protein 41; SGT1 = suppressor of G2 allele of SKP1)
      Title: Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1.
    5. Fusion of human SGT1 (hSGT1) to NOD1 LRR significantly enhanced the solubility, and the fusion protein was stabilized by coexpression of mouse Hsp90alpha.
      Title: Application of SGT1-Hsp90 chaperone complex for soluble expression of NOD1 LRR domain in E. coli.
    6. Data (including data from studies using purified proteins/hepatocyte lysates) suggest eEF1A1/Sgt1a interact as multimer; D2/D3 domains of eEF1A1 and TPR domain of Sgt1 are involved in multimer formation; Sgt1 competes with viral RNA to bind to eEF1A.
      Title: Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1.
    7. Data suggest that SspH2 (ubiquitin ligase effector from Salmonella typhimurium) ubiquitination activity and protein stability is enhanced by SGT1.
      Title: The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity.
    8. our data revealed a previously uncovered role of SGT1 in gastric cancer development, and suggested that SGT1 could be a promising anti-cancer target to against gastric cancer
      Title: SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells.
    9. Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner
      Title: Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1.
    10. Plk1 is required for the kinetochore localization of Sgt1 and phosphorylates serine 331 of Sgt1 at the kinetochores.
      Title: Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lncRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein stability IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in skeletal muscle satellite cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein SGT1 homolog
    Names
    SGT1, suppressor of G2 allele of SKP1
    putative 40-6-3 protein
    suppressor of G2 allele of SKP1, S. cerevisiae, homolog of

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029521.3 RefSeqGene

      Range
      5002..53075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130912.3 → NP_001124384.1  protein SGT1 homolog isoform B

      See identical proteins and their annotated locations for NP_001124384.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as B or SGT1.2) encodes the longest isoform (B).
      Source sequence(s)
      AL139089
      Consensus CDS
      CCDS45050.1
      UniProtKB/Swiss-Prot
      A2A303, Q5JAK5, Q5TAM6, Q6VXY6, Q9Y2Z0
      UniProtKB/TrEMBL
      A8K5T7
      Related
      ENSP00000367208.4, ENST00000343788.10
      Conserved Domains (2) summary
      PLN03088
      Location:21 → 365
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:44 → 74
      TPR; TPR repeat [structural motif]

    2. NM_001320831.2 → NP_001307760.1  protein SGT1 homolog isoform C

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon and contains an alternate exon in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform B.
      Source sequence(s)
      AL139089
      UniProtKB/TrEMBL
      B4DYC6
      Conserved Domains (2) summary
      sd00006
      Location:22 → 52
      TPR; TPR repeat [structural motif]
      cl26005
      Location:8 → 277
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    3. NM_006704.5 → NP_006695.1  protein SGT1 homolog isoform A

      See identical proteins and their annotated locations for NP_006695.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as A) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (A) is shorter than isoform B.
      Source sequence(s)
      AL139089
      Consensus CDS
      CCDS9436.1
      UniProtKB/TrEMBL
      A8K7W3
      Related
      ENSP00000308067.7, ENST00000310528.9
      Conserved Domains (2) summary
      sd00006
      Location:44 → 74
      TPR; TPR repeat [structural motif]
      cl26005
      Location:21 → 333
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      52652836..52700909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020365.2 → XP_016875854.1  protein SGT1 homolog isoform X1

      UniProtKB/TrEMBL
      A8K5T7

    2. XM_047430066.1 → XP_047286022.1  protein SGT1 homolog isoform X3

    3. XM_047430065.1 → XP_047286021.1  protein SGT1 homolog isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      51868272..51916337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374052.1 → XP_054230027.1  protein SGT1 homolog isoform X1

    2. XM_054374053.1 → XP_054230028.1  protein SGT1 homolog isoform X2

    3. XM_054374054.1 → XP_054230029.1  protein SGT1 homolog isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2Z0.3 GenPept UniProtKB/Swiss-Prot:Q9Y2Z0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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