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    Chst1 carbohydrate sulfotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 76969, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Chst1provided by MGI
    Official Full Name
    carbohydrate sulfotransferase 1provided by MGI
    Primary source
    MGI:MGI:1924219
    See related
    Ensembl:ENSMUSG00000027221 AllianceGenome:MGI:1924219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C6ST; Gst1; KSST; GST-1; KS6ST; KSGAL6ST; 2610008E20Rik
    Summary
    Predicted to enable N-acetylglucosamine 6-O-sulfotransferase activity and keratan sulfotransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process; galactose metabolic process; and keratan sulfate biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in trans-Golgi network. Is expressed in eye; limb; and nervous system. Orthologous to human CHST1 (carbohydrate sulfotransferase 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 51.0), cortex adult (RPKM 49.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chst1 in Genome Data Viewer
    Location:
    2 E1; 2 51.17 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (92429978..92445597)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (92599632..92615252)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene microRNA 7221 Neighboring gene microRNA 7222 Neighboring gene STARR-seq mESC enhancer starr_05147 Neighboring gene STARR-seq mESC enhancer starr_05149 Neighboring gene STARR-seq mESC enhancer starr_05150 Neighboring gene predicted gene 13816 Neighboring gene predicted gene, 39880 Neighboring gene predicted gene, 32413

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency. Kumagai T, et al. Glycobiology, 2018 Jun 1. PMID 29659839, Free PMC Article
    2. Preferential expression of sialyl 6'-sulfo N-acetyllactosamine-capped O-glycans on high endothelial venules in human peripheral lymph nodes. Tsutsumiuchi M, et al. Lab Invest, 2019 Oct. PMID 31148596
    3. Microglial keratan sulfate epitope elicits in central nervous tissues of transgenic model mice and patients with amyotrophic lateral sclerosis. Foyez T, et al. Am J Pathol, 2015 Nov. PMID 26362733
    4. KSGal6ST is essential for the 6-sulfation of galactose within keratan sulfate in early postnatal brain. Hoshino H, et al. J Histochem Cytochem, 2014 Feb. PMID 24152993, Free PMC Article
    5. Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis. Yang J, et al. BMC Immunol, 2006 Jun 13. PMID 16772045, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CHST1 does not contribute to the synthesis of glycan ligands for Siglec-F in the airways, although its absence results in exaggerated accumulation of airway macrophages and lymphocytes.
      Title: Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency.
    2. KSGal6ST is essential for C-6 sulfation of Gal within keratan sulfate in early postnatal brains.
      Title: KSGal6ST is essential for the 6-sulfation of galactose within keratan sulfate in early postnatal brain.
    3. neither KSGal6ST nor C6ST-1 is required for Siglec-F ligand synthesis in leukocytes or lung tissue
      Title: Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables keratan sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables keratan sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables keratan sulfotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in keratan sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratan sulfate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in keratan sulfate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratan sulfate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfur compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 1
    Names
    N-acetylglucosamine-6-O-sulfotransferase 1
    carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
    galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1
    keratan sulfate Gal-6 sulfotransferase
    NP_001343481.1
    NP_001343482.1
    NP_076339.1
    XP_030108062.1
    XP_030108063.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356552.1 → NP_001343481.1  carbohydrate sulfotransferase 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AL683814
      Consensus CDS
      CCDS16450.1
      UniProtKB/Swiss-Prot
      Q9D0K5, Q9EQC0
      UniProtKB/TrEMBL
      Q3UY35
      Conserved Domains (1) summary
      pfam00685
      Location:198 → 384
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_001356553.1 → NP_001343482.1  carbohydrate sulfotransferase 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AL683814
      Consensus CDS
      CCDS16450.1
      UniProtKB/Swiss-Prot
      Q9D0K5, Q9EQC0
      UniProtKB/TrEMBL
      Q3UY35
      Conserved Domains (1) summary
      pfam00685
      Location:198 → 384
      Sulfotransfer_1; Sulfotransferase domain

    3. NM_023850.2 → NP_076339.1  carbohydrate sulfotransferase 1

      See identical proteins and their annotated locations for NP_076339.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK011344, AK134997, CX238855
      Consensus CDS
      CCDS16450.1
      UniProtKB/Swiss-Prot
      Q9D0K5, Q9EQC0
      UniProtKB/TrEMBL
      Q3UY35
      Related
      ENSMUSP00000064246.7, ENSMUST00000065797.7
      Conserved Domains (1) summary
      pfam00685
      Location:198 → 384
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      92429978..92445597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252202.2 → XP_030108062.1  carbohydrate sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9D0K5, Q9EQC0
      UniProtKB/TrEMBL
      Q3UY35
      Conserved Domains (1) summary
      pfam00685
      Location:198 → 384
      Sulfotransfer_1; Sulfotransferase domain

    2. XM_030252203.2 → XP_030108063.1  carbohydrate sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9D0K5, Q9EQC0
      UniProtKB/TrEMBL
      Q3UY35
      Conserved Domains (1) summary
      pfam00685
      Location:198 → 384
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQC0.1 GenPept UniProtKB/Swiss-Prot:Q9EQC0

    Gene LinkOut

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