Akap3 A kinase anchor protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akap3provided by MGI
Official Full Name: A kinase anchor protein 3provided by MGI
Primary source: MGI:MGI:1341149
See related: Ensembl:ENSMUSG00000030344 AllianceGenome:MGI:1341149
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prka3
Summary: Enables protein kinase A binding activity. Involved in establishment of protein localization and flagellated sperm motility. Acts upstream of or within blastocyst hatching; cell surface receptor protein serine/threonine kinase signaling pathway; and protein localization. Located in acrosomal vesicle and sperm principal piece. Is active in sperm fibrous sheath. Is expressed in early conceptus; secondary oocyte; and spermatocyte. Human ortholog(s) of this gene implicated in spermatogenic failure 82. Orthologous to human AKAP3 (A-kinase anchoring protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 181.3) See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 61.92 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (126830061..126851271)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (126853098..126874308)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AKAP3-mediated type I PKA signaling is required for mouse sperm hyperactivation and fertilitydagger.
Title: AKAP3-mediated type I PKA signaling is required for mouse sperm hyperactivation and fertility†.
MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling pathway.
Title: MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling pathway.
AKAP3 is essential for the formation of the specific subcellular structure of the sperm flagellum, motility of sperm and male fertility.
Title: Lack of AKAP3 disrupts integrity of the subcellular structure and proteome of mouse sperm and causes male sterility.
Studied PKA subunit isoform expression in meiotic and post-meiotic mouse spermatogenic cells, and found sperm-specific AKAP3 can be found in the cytoplasm of elongating spermatids and interacts with RIalpha.
Title: Sperm-specific AKAP3 is a dual-specificity anchoring protein that interacts with both protein kinase a regulatory subunits via conserved N-terminal amphipathic peptides.
We analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.
Title: AKAP3 synthesis is mediated by RNA binding proteins and PKA signaling during mouse spermiogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in sperm fibrous sheath	IDA Inferred from Direct Assay more info	PubMed
located_in sperm fibrous sheath	IDA Inferred from Direct Assay more info	PubMed
located_in sperm midpiece	IEA Inferred from Electronic Annotation more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
is_active_in sperm principal piece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm principal piece	IDA Inferred from Direct Assay more info	PubMed
located_in sperm principal piece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-kinase anchor protein 3

Names: A kinase (PRKA) anchor protein 3; A-kinase anchor protein 110 kDa; AKAP 110; AKAP-3; Protein kinase A-anchoring protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.