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    Cmklr1 chemerin chemokine-like receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 14747, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cmklr1provided by MGI
    Official Full Name
    chemerin chemokine-like receptor 1provided by MGI
    Primary source
    MGI:MGI:109603
    See related
    Ensembl:ENSMUSG00000042190 AllianceGenome:MGI:109603
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DEZ; Gpcr27; ChemR23; mcmklr1
    Summary
    Predicted to enable adipokinetic hormone binding activity; adipokinetic hormone receptor activity; and transmembrane signaling receptor activity. Involved in negative regulation of interleukin-12 production; positive regulation of cold-induced thermogenesis; and positive regulation of fat cell differentiation. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; embryo mesenchyme; jaw; lung; and uterus. Orthologous to human CMKLR1 (chemerin chemokine-like receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 58.5), subcutaneous fat pad adult (RPKM 38.4) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cmklr1 in Genome Data Viewer
    Location:
    5 F; 5 55.55 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113750415..113792971, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113612355..113650475, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30812 Neighboring gene WSC domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_14042 Neighboring gene predicted gene, 52822 Neighboring gene STARR-seq mESC enhancer starr_14044 Neighboring gene STARR-seq mESC enhancer starr_14048 Neighboring gene STARR-seq mESC enhancer starr_14049 Neighboring gene predicted gene 15736 Neighboring gene predicted gene, 52823 Neighboring gene RIKEN cDNA 1700069L16 gene Neighboring gene predicted gene, 46919 Neighboring gene STARR-positive B cell enhancer ABC_E2171 Neighboring gene FIC domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance. Ernst MC, et al. Endocrinology, 2012 Feb. PMID 22186410, Free PMC Article
    2. Chemokine-Like Receptor 1 Is a Novel Wnt Target Gene that Regulates Mesenchymal Stem Cell Differentiation. Muruganandan S, et al. Stem Cells, 2017 Mar. PMID 27733019
    3. CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone. Tang M, et al. Sci Rep, 2016 Feb 19. PMID 26893072, Free PMC Article
    4. Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues. Hansen IR, et al. Biochim Biophys Acta, 2014 Dec. PMID 25224322
    5. Inconsequential role for chemerin-like receptor 1 in the manifestation of ozone-induced lung pathophysiology in male mice. Johnston RA, et al. Physiol Rep, 2024 Apr. PMID 38631890, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.
      Title: The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.
    2. ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke.
      Title: ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke.
    3. Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice.
      Title: Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice.
    4. miR-22-3p ameliorates the symptoms of premature ovarian failure in mice by inhibiting CMKLR1 expression.
      Title: miR-22-3p ameliorates the symptoms of premature ovarian failure in mice by inhibiting CMKLR1 expression.
    5. n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.
      Title: n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.
    6. The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease.
      Title: The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease.
    7. Chemokine-like receptor 1 deficiency impedes macrophage phenotypic transformation and cardiac repair after myocardial infarction.
      Title: Chemokine-like receptor 1 deficiency impedes macrophage phenotypic transformation and cardiac repair after myocardial infarction.
    8. ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation.
      Title: ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation.
    9. The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Abeta Deposition through p38 MAPK Pathway.
      Title: The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Deposition through p38 MAPK Pathway.
    10. Epithelial chemerin-CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase.
      Title: Epithelial chemerin-CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adipokinetic hormone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adipokinetic hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables adipokinetic hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adipokinetic hormone receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables complement receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of macrophage chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    chemerin-like receptor 1
    Names
    G-protein coupled receptor 27
    G-protein coupled receptor DEZ
    chemerin receptor
    chemokine receptor-like 1
    chemokine-like receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359060.1 → NP_001345989.1  chemerin-like receptor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC241893, CJ072893
      Consensus CDS
      CCDS19551.1
      UniProtKB/Swiss-Prot
      P97468
      UniProtKB/TrEMBL
      E9Q8N2, Q497D3
      Conserved Domains (1) summary
      cd15116
      Location:39 → 325
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_008153.3 → NP_032179.1  chemerin-like receptor 1

      See identical proteins and their annotated locations for NP_032179.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC241893, BY347978
      Consensus CDS
      CCDS19551.1
      UniProtKB/Swiss-Prot
      P97468
      UniProtKB/TrEMBL
      E9Q8N2, Q497D3
      Related
      ENSMUSP00000036316.7, ENSMUST00000047936.13
      Conserved Domains (1) summary
      cd15116
      Location:39 → 325
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      113750415..113792971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164795.1 → XP_036020688.1  chemerin-like receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      P97468
      UniProtKB/TrEMBL
      E9Q8N2, Q497D3
      Conserved Domains (1) summary
      cd15116
      Location:39 → 325
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_006530164.5 → XP_006530227.1  chemerin-like receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006530227.1

      UniProtKB/Swiss-Prot
      P97468
      UniProtKB/TrEMBL
      E9Q8N2, Q497D3
      Conserved Domains (1) summary
      cd15116
      Location:39 → 325
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_006530166.3 → XP_006530229.1  chemerin-like receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006530229.1

      UniProtKB/Swiss-Prot
      P97468
      UniProtKB/TrEMBL
      E9Q8N2, Q497D3
      Related
      ENSMUSP00000121765.2, ENSMUST00000132065.8
      Conserved Domains (1) summary
      cd15116
      Location:39 → 325
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_006530165.4 → XP_006530228.1  chemerin-like receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006530228.1

      UniProtKB/Swiss-Prot
      P97468
      UniProtKB/TrEMBL
      E9Q8N2, Q497D3
      Conserved Domains (1) summary
      cd15116
      Location:39 → 325
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97468.1 GenPept UniProtKB/Swiss-Prot:P97468

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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