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    Zfp444 zinc finger protein 444 [ Mus musculus (house mouse) ]

    Gene ID: 72667, updated on 2-Nov-2024

    Summary

    Official Symbol
    Zfp444provided by MGI
    Official Full Name
    zinc finger protein 444provided by MGI
    Primary source
    MGI:MGI:1923365
    See related
    Ensembl:ENSMUSG00000044876 AllianceGenome:MGI:1923365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mFLJ00134; 2810031J10Rik; 6230401O10Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in brain; frontal cortex; liver; placenta; and testis. Orthologous to human ZNF444 (zinc finger protein 444). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.1), whole brain E14.5 (RPKM 10.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Zfp444 in Genome Data Viewer
    Location:
    7 A1; 7 3.58 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6175429..6196103)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6172468..6193104)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 18758 Neighboring gene zinc finger protein 787 Neighboring gene STARR-positive B cell enhancer ABC_E9284 Neighboring gene predicted gene, 36371 Neighboring gene STARR-positive B cell enhancer ABC_E4893 Neighboring gene STARR-seq mESC enhancer starr_17966 Neighboring gene galanin-like peptide Neighboring gene zinc finger and SCAN domain containing 5B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146024.1NP_001139496.1  zinc finger protein 444

      See identical proteins and their annotated locations for NP_001139496.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC148989, AK018079, BC139361
      Consensus CDS
      CCDS20770.1
      UniProtKB/TrEMBL
      Q3TDV8, Q8BJ97
      Related
      ENSMUSP00000104206.2, ENSMUST00000108566.8
      Conserved Domains (4) summary
      COG5048
      Location:186284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:26103
      SCAN; SCAN domain
    2. NM_028316.3NP_082592.2  zinc finger protein 444

      See identical proteins and their annotated locations for NP_082592.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC148989, AK018079, BC139361
      Consensus CDS
      CCDS20770.1
      UniProtKB/TrEMBL
      Q3TDV8, Q8BJ97
      Related
      ENSMUSP00000050797.6, ENSMUST00000054680.12
      Conserved Domains (4) summary
      COG5048
      Location:186284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:26103
      SCAN; SCAN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      6175429..6196103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540381.5XP_006540444.1  zinc finger protein 444 isoform X1

      See identical proteins and their annotated locations for XP_006540444.1

      UniProtKB/TrEMBL
      Q3TDV8, Q8BJ97
      Conserved Domains (4) summary
      COG5048
      Location:186284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:26103
      SCAN; SCAN domain
    2. XM_006540382.4XP_006540445.1  zinc finger protein 444 isoform X1

      See identical proteins and their annotated locations for XP_006540445.1

      UniProtKB/TrEMBL
      Q3TDV8, Q8BJ97
      Conserved Domains (4) summary
      COG5048
      Location:186284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:26103
      SCAN; SCAN domain
    3. XM_006540380.5XP_006540443.1  zinc finger protein 444 isoform X1

      See identical proteins and their annotated locations for XP_006540443.1

      UniProtKB/TrEMBL
      Q3TDV8, Q8BJ97
      Conserved Domains (4) summary
      COG5048
      Location:186284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:26103
      SCAN; SCAN domain
    4. XM_006540383.5XP_006540446.1  zinc finger protein 444 isoform X1

      See identical proteins and their annotated locations for XP_006540446.1

      UniProtKB/TrEMBL
      Q3TDV8, Q8BJ97
      Conserved Domains (4) summary
      COG5048
      Location:186284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:282304
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:26103
      SCAN; SCAN domain