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    Zfp667 zinc finger protein 667 [ Mus musculus (house mouse) ]

    Gene ID: 384763, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp667provided by MGI
    Official Full Name
    zinc finger protein 667provided by MGI
    Primary source
    MGI:MGI:2442757
    See related
    Ensembl:ENSMUSG00000054893 AllianceGenome:MGI:2442757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mip1; ZNF667; A830025F02Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in limb. Orthologous to human ZNF667 (zinc finger protein 667). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 4.5), bladder adult (RPKM 2.2) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp667 in Genome Data Viewer
    Location:
    7 A1; 7 3.64 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6289187..6310882)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6286195..6307883)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 5B Neighboring gene STARR-seq mESC enhancer starr_17972 Neighboring gene epididymal protein 13 Neighboring gene STARR-positive B cell enhancer ABC_E11341 Neighboring gene STARR-seq mESC enhancer starr_17975 Neighboring gene STARR-positive B cell enhancer ABC_E4894 Neighboring gene zinc finger protein 583 Neighboring gene predicted gene, 38944 Neighboring gene zinc finger protein 582

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mipu1 inhibits lipid accumulation through down-regulation of CD36 in RAW264.7 cells. Qu SL, et al. Cell Physiol Biochem, 2015. PMID 26383633
    2. IL9 Polarizes Macrophages to M1 and Induces the Infiltration of Antitumor Immune Cells via MIP-1 and CXCR3 Chemokines. Do-Thi VA, et al. Cancer Res Commun, 2023 Jan. PMID 36968220, Free PMC Article
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 667
    Names
    myocardial ischemic preconditioning up-regulated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024928.2 → NP_001020099.1  zinc finger protein 667

      See identical proteins and their annotated locations for NP_001020099.1

      Status: VALIDATED

      Source sequence(s)
      AY850275
      Consensus CDS
      CCDS20773.1
      UniProtKB/Swiss-Prot
      B2RUH6, Q2TL60
      Related
      ENSMUSP00000083507.6, ENSMUST00000086327.12
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      6289187..6310882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540156.5 → XP_006540219.1  zinc finger protein 667 isoform X1

      See identical proteins and their annotated locations for XP_006540219.1

      UniProtKB/Swiss-Prot
      B2RUH6, Q2TL60
      Related
      ENSMUSP00000104202.2, ENSMUST00000108562.2
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_036153211.1 → XP_036009104.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RUH6, Q2TL60
      Related
      ENSMUSP00000128658.2, ENSMUST00000170776.8
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_017322332.3 → XP_017177821.1  zinc finger protein 667 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:225 → 385
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:285 → 305
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_006540154.4 → XP_006540217.1  zinc finger protein 667 isoform X1

      See identical proteins and their annotated locations for XP_006540217.1

      UniProtKB/Swiss-Prot
      B2RUH6, Q2TL60
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_006540153.5 → XP_006540216.1  zinc finger protein 667 isoform X1

      See identical proteins and their annotated locations for XP_006540216.1

      UniProtKB/Swiss-Prot
      B2RUH6, Q2TL60
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_036153210.1 → XP_036009103.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RUH6, Q2TL60
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_006540155.1 → XP_006540218.1  zinc finger protein 667 isoform X1

      See identical proteins and their annotated locations for XP_006540218.1

      UniProtKB/Swiss-Prot
      B2RUH6, Q2TL60
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_011250620.4 → XP_011248922.1  zinc finger protein 667 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:65 → 524
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:424 → 444
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2TL60.1 GenPept UniProtKB/Swiss-Prot:Q2TL60

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