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    Nna1 Nna1 carboxypeptidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32329, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nna1provided by FlyBase
    Official Full Name
    Nna1 carboxypeptidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265726
    Locus tag
    Dmel_CG44533
    See related
    AllianceGenome:FB:FBgn0265726
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11428; CG32627; CG32628; CG44533; Dmel\CG44533; Nnad; NnaD
    Old locus tag
    Dmel_CG32627; Dmel_CG32628
    Summary
    Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Involved in larval development and mitochondrion organization. Located in mitochondrion. Is expressed in embryonic/larval optic lobe; larval brain; larval ventral nerve cord; and spermatozoon. Orthologous to several human genes including AGBL3 (AGBL carboxypeptidase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Nna1 in Genome Data Viewer
    Location:
    12B3-12B4; 1-45 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13692292..13717835)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13586325..13611868)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NAD synthetase Neighboring gene Mahogunin ring finger 1 Neighboring gene mutagen-sensitive 101

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial dysfunction in NnaD mutant flies and Purkinje cell degeneration mice reveals a role for Nna proteins in neuronal bioenergetics. Chakrabarti L, et al. Neuron, 2010 Jun 24. PMID 20620870, Free PMC Article
    2. CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice. Gilmore-Hall S, et al. J Cell Biol, 2019 Jan 7. PMID 30337352, Free PMC Article
    3. Exploring the multilevel hazards of thiamethoxam using Drosophila melanogaster. Li X, et al. J Hazard Mater, 2020 Feb 15. PMID 31630861
    4. α-amanitin resistance in Drosophila melanogaster: A genome-wide association approach. Mitchell CL, et al. PLoS One, 2017. PMID 28241077, Free PMC Article
    5. Molecular toxicity and defense mechanisms induced by silver nanoparticles in Drosophila melanogaster. Wang Z, et al. J Environ Sci (China), 2023 Mar. PMID 36375944

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nna1 carboxypeptidase
    Names
    CG44533-PA
    CG44533-PB
    CG44533-PC
    CG44533-PD
    CG44533-PE
    CG44533-PF
    CG44533-PG
    CG44533-PH
    CG44533-PI
    CG44533-PJ
    Nna1-PA
    Nna1-PB
    Nna1-PC
    Nna1-PD
    Nna1-PE
    Nna1-PF
    Nna1-PG
    Nna1-PH
    Nna1-PI
    Nna1-PJ
    drosophila Nna1 ortholog
    NP_001096975.1
    NP_001245655.1
    NP_001245656.1
    NP_001245657.1
    NP_001285225.1
    NP_001285226.1
    NP_001285227.1
    NP_572914.2
    NP_727728.1
    NP_788899.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13692292..13717835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298296.1 → NP_001285225.1  Nna1 carboxypeptidase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285225.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JBR4
      Conserved Domains (2) summary
      cd06907
      Location:771 → 1031
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      COG2866
      Location:625 → 886
      MpaA; Murein tripeptide amidase MpaA [Cell wall/membrane/envelope biogenesis]

    2. NM_001298297.1 → NP_001285226.1  Nna1 carboxypeptidase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285226.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JDN6
      Conserved Domains (2) summary
      cd06907
      Location:771 → 1031
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      COG2866
      Location:625 → 886
      MpaA; Murein tripeptide amidase MpaA [Cell wall/membrane/envelope biogenesis]

    3. NM_001298298.1 → NP_001285227.1  Nna1 carboxypeptidase, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285227.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JK43
      Conserved Domains (2) summary
      cd06907
      Location:771 → 1031
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      COG2866
      Location:625 → 886
      MpaA; Murein tripeptide amidase MpaA [Cell wall/membrane/envelope biogenesis]

    4. NM_001258726.1 → NP_001245655.1  Nna1 carboxypeptidase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245655.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NGD4
      Conserved Domains (2) summary
      cd06907
      Location:771 → 1031
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      COG2866
      Location:625 → 886
      MpaA; Murein tripeptide amidase MpaA [Cell wall/membrane/envelope biogenesis]

    5. NM_132686.3 → NP_572914.2  Nna1 carboxypeptidase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572914.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JUW0, C7LAD7, Q86B56, Q8T9D7, Q9VY99
      Related
      FBpp0309513
      Conserved Domains (2) summary
      cd06907
      Location:883 → 1143
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      COG2866
      Location:737 → 998
      MpaA; Murein tripeptide amidase MpaA [Cell wall/membrane/envelope biogenesis]

    6. NM_167379.2 → NP_727728.1  Nna1 carboxypeptidase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727728.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VY99
      Related
      FBpp0309514
      Conserved Domains (2) summary
      cd06907
      Location:619 → 879
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      COG2866
      Location:473 → 734
      MpaA; Murein tripeptide amidase MpaA [Cell wall/membrane/envelope biogenesis]

    7. NM_001258728.1 → NP_001245657.1  Nna1 carboxypeptidase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245657.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF40
      Conserved Domains (3) summary
      cd06907
      Location:430 → 690
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      COG2866
      Location:284 → 545
      MpaA; Murein tripeptide amidase MpaA [Cell wall/membrane/envelope biogenesis]
      cl01640
      Location:686 → 731
      DUF2098; Uncharacterized protein conserved in archaea (DUF2098)

    8. NM_001103505.3 → NP_001096975.1  Nna1 carboxypeptidase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096975.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VY99
      Conserved Domains (2) summary
      cd06907
      Location:766 → 1026
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      COG2866
      Location:620 → 881
      MpaA; Murein tripeptide amidase MpaA [Cell wall/membrane/envelope biogenesis]

    9. NM_176726.2 → NP_788899.1  Nna1 carboxypeptidase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788899.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEF7
      Related
      FBpp0309515
      Conserved Domains (2) summary
      cd06907
      Location:595 → 855
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      COG2866
      Location:449 → 710
      MpaA; Murein tripeptide amidase MpaA [Cell wall/membrane/envelope biogenesis]

    10. NM_001258727.1 → NP_001245656.1  Nna1 carboxypeptidase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245656.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEF7
      Conserved Domains (2) summary
      cd06907
      Location:595 → 855
      M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
      COG2866
      Location:449 → 710
      MpaA; Murein tripeptide amidase MpaA [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NEF7 M9NEF7
    M9NF40 M9NF40
    M9NGD4 M9NGD4
    Q5BHW8 Q5BHW8
    Q9VY99.2 Q9VY99
    X2JBR4 X2JBR4
    X2JDN6 X2JDN6
    X2JK43 X2JK43

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