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    Galnt10 polypeptide N-acetylgalactosaminyltransferase 10 [ Mus musculus (house mouse) ]

    Gene ID: 171212, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Galnt10provided by MGI
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 10provided by MGI
    Primary source
    MGI:MGI:1890480
    See related
    Ensembl:ENSMUSG00000020520 AllianceGenome:MGI:1890480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Galnt9; GalNAc-T9; ppGaNTase; GalNAc-T10; C330012K04Rik
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Acts upstream of or within protein O-linked glycosylation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; brain; eye; integumental system; and limb. Orthologous to human GALNT10 (polypeptide N-acetylgalactosaminyltransferase 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 25.4), large intestine adult (RPKM 14.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Galnt10 in Genome Data Viewer
    Location:
    11 B1.3; 11 35.27 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (57536268..57678327)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (57645442..57787514)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 114, member A2 Neighboring gene STARR-positive B cell enhancer ABC_E1825 Neighboring gene microfibrillar-associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_29572 Neighboring gene predicted gene, 51895 Neighboring gene RIKEN cDNA 4933424L21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:57458544-57458653 Neighboring gene predicted gene, 51896 Neighboring gene predicted gene, 46282 Neighboring gene STARR-seq mESC enhancer starr_29577 Neighboring gene predicted gene, 24582 Neighboring gene RIKEN cDNA 2010001A14 gene Neighboring gene STARR-positive B cell enhancer ABC_E5228 Neighboring gene predicted gene, 53707

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A new UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase mRNA exhibits predominant expression in the hypothalamus, thalamus and amygdala of mouse forebrain. Nelson PA, et al. Brain Res Gene Expr Patterns, 2002 Jan. PMID 15018805
    2. Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9. Ten Hagen KG, et al. J Biol Chem, 2001 May 18. PMID 11278534
    3. Diverse spatial expression patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase family member mRNAs during mouse development. Kingsley PD, et al. Glycobiology, 2000 Dec. PMID 11159923
    4. Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function. Vincentz JW, et al. Circ Res, 2019 Aug 30. PMID 31366290, Free PMC Article
    5. Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans. Yoshida CA, et al. J Biol Chem, 2014 Sep 19. PMID 25107907, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GALNT10 exhibits predominant expression in the hypothalamus, thalamus and amygdala of mouse forebrain
      Title: A new UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase mRNA exhibits predominant expression in the hypothalamus, thalamus and amygdala of mouse forebrain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in O-glycan processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 10
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10
    UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 9
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10
    polypeptide GalNAc transferase 10
    pp-GaNTase 10
    protein-UDP acetylgalactosaminyltransferase 10
    NP_598950.2
    XP_006532454.1
    XP_030101480.1
    XP_030101481.1
    XP_030101482.1
    XP_036012265.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134189.2 → NP_598950.2  polypeptide N-acetylgalactosaminyltransferase 10

      See identical proteins and their annotated locations for NP_598950.2

      Status: VALIDATED

      Source sequence(s)
      AK033515, BB626609, BC060617
      Consensus CDS
      CCDS24719.1
      UniProtKB/Swiss-Prot
      Q6KAQ2, Q6P9S7, Q8BZU8, Q91YJ6
      UniProtKB/TrEMBL
      Q3TXV9, Q5SQF9
      Related
      ENSMUSP00000065096.8, ENSMUST00000066987.14
      Conserved Domains (4) summary
      cd02510
      Location:148 → 443
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:144 → 443
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:461 → 589
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:459 → 587
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      57536268..57678327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156372.1 → XP_036012265.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X2

      Conserved Domains (2) summary
      cd02510
      Location:1 → 244
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:260 → 388
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. XM_030245621.2 → XP_030101481.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X1

      UniProtKB/TrEMBL
      Q3TXV9
      Conserved Domains (2) summary
      cd02510
      Location:51 → 346
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:362 → 490
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    3. XM_030245620.2 → XP_030101480.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X1

      UniProtKB/TrEMBL
      Q3TXV9
      Conserved Domains (2) summary
      cd02510
      Location:51 → 346
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:362 → 490
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    4. XM_030245622.2 → XP_030101482.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X2

      Conserved Domains (2) summary
      cd02510
      Location:1 → 244
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:260 → 388
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    5. XM_006532391.4 → XP_006532454.1  polypeptide N-acetylgalactosaminyltransferase 10 isoform X1

      See identical proteins and their annotated locations for XP_006532454.1

      UniProtKB/TrEMBL
      Q3TXV9
      Conserved Domains (2) summary
      cd02510
      Location:51 → 346
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:362 → 490
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P9S7.1 GenPept UniProtKB/Swiss-Prot:Q6P9S7

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