Arid5b AT-rich interaction domain 5B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arid5bprovided by MGI
Official Full Name: AT-rich interaction domain 5Bprovided by MGI
Primary source: MGI:MGI:2175912
See related: Ensembl:ENSMUSG00000019947 AllianceGenome:MGI:2175912
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mrf2; Desrt; Mrf2beta; Mrf2alpha; 4930580B11; 5430435G07Rik
Summary: Predicted to enable transcription cis-regulatory region binding activity and transcription coactivator activity. Involved in adipose tissue development. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; face morphogenesis; and gonad development. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human ARID5B (AT-rich interaction domain 5B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 5.8), bladder adult (RPKM 5.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B5.1- B5.2; 10 35.14 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (67928353..68114596, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (68092523..68279355, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development.
Title: ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development.
ARID5B influences B-cell development and function in mouse.
Title: ARID5B influences B-cell development and function in mouse.
Muscle-specific deletion of Arid5b causes metabolic changes in skeletal muscle that affect adipose tissue and liver.
Title: Muscle-specific deletion of Arid5b causes metabolic changes in skeletal muscle that affect adipose tissue and liver.
Mice with Fabp4-Cre ablation of Arid5b are resistant to diet-induced obesity and hepatic steatosis.
Title: Mice with Fabp4-Cre ablation of Arid5b are resistant to diet-induced obesity and hepatic steatosis.
Arid5b KO reduces prostaglandin I2 signaling in primary skeletal muscle cells and attenuates myogenesis.
Title: Reduced prostaglandin I(2) signaling in Arid5b(-/-) primary skeletal muscle cells attenuates myogenesis.
These results strongly suggest that p62 plays a crucial role in preventing fenofibrate-induced cell death.
Title: Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation.
Arid5b recruits Phf2 to the promoter region of Sox9 target genes and stimulates H3K9me2 demethylation of these genes.
Title: Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes.
knockdown of Mrf-2 increases the rate of fatty acid recycling in 3T3-L1-derived adipocytes.
Title: Modulator recognition factor-2 regulates triglyceride metabolism in adipocytes.
Data suggest that Mrf-2 facilitates the induction of key adipogenic transcription factors C/EBPalpha and peroxisome proliferator-activated receptor-gamma.
Title: Modulator recognition factor-2 is required for adipogenesis in mouse embryo fibroblasts and 3T3-L1 cells.
These results indicate that Mrf2 can be a potential regulator of adipocyte differentiation and a potential repressor of leptin.
Title: Role of modulator recognition factor 2 in adipogenesis and leptin expression in 3T3-L1 cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BG377178 (e-PCR)
- UniSTS:244489

RH126795 (e-PCR)
- UniSTS:209740

D10Mit31 (e-PCR), detects polymorphism
- UniSTS:116374

D10Mit223 (e-PCR), detects polymorphism
- UniSTS:126127

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adrenal gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within excretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within face morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fat pad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: AT-rich interactive domain-containing protein 5B

Names: ARID class DNA binding protein; ARID domain-containing protein 5B; AT rich interactive domain 5B (MRF1-like); AT rich interactive domain 5B (Mrf1 like); MRF-2; developmentally and sexually retarded with transient immune abnormalities protein; modulator recognition factor 2; modulator recognition factor protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023598.2 → NP_076087.2 AT-rich interactive domain-containing protein 5B

See identical proteins and their annotated locations for NP_076087.2

Status: VALIDATED

Source sequence(s)

AK029818, AK034633, BY717211, BY720203, CD543091, CN665657

Consensus CDS

CCDS35929.1

UniProtKB/Swiss-Prot

E9Q523, Q8BM75, Q8C0E0, Q8K4G8, Q8K4L9, Q9CU78, Q9JIX4

Related

ENSMUSP00000151227.2, ENSMUST00000219238.2

Conserved Domains (2) summary

PTZ00121
Location:411 → 536

PTZ00121; MAEBL; Provisional

cd16885
Location:321 → 415

ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

67928353..68114596 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245282.2 → XP_030101142.1 AT-rich interactive domain-containing protein 5B isoform X3

Conserved Domains (2) summary

PTZ00121
Location:222 → 347

PTZ00121; MAEBL; Provisional

cd16885
Location:132 → 226

ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins
XM_006514129.4 → XP_006514192.1 AT-rich interactive domain-containing protein 5B isoform X1

Conserved Domains (2) summary

PTZ00121
Location:437 → 562

PTZ00121; MAEBL; Provisional

cd16885
Location:347 → 441

ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins
XM_006514132.2 → XP_006514195.1 AT-rich interactive domain-containing protein 5B isoform X3

See identical proteins and their annotated locations for XP_006514195.1

Conserved Domains (2) summary

PTZ00121
Location:222 → 347

PTZ00121; MAEBL; Provisional

cd16885
Location:132 → 226

ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins
XM_006514131.4 → XP_006514194.1 AT-rich interactive domain-containing protein 5B isoform X2

Related

ENSMUSP00000151665.2, ENSMUST00000218532.2

Conserved Domains (2) summary

PTZ00121
Location:225 → 350

PTZ00121; MAEBL; Provisional

cd16885
Location:135 → 229

ARID_ARID5B; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 5B (ARID5B) and similar proteins
XM_036156016.1 → XP_036011909.1 AT-rich interactive domain-containing protein 5B isoform X4

Conserved Domains (2) summary

PTZ00121
Location:79 → 204

PTZ00121; MAEBL; Provisional

cl28902
Location:1 → 83

ARID; ARID/BRIGHT DNA binding domain family