Stx3 syntaxin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stx3provided by MGI
Official Full Name: syntaxin 3provided by MGI
Primary source: MGI:MGI:103077
See related: Ensembl:ENSMUSG00000041488 AllianceGenome:MGI:103077
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Syn-3
Summary: Predicted to enable SNAP receptor activity; SNARE binding activity; and arachidonate binding activity. Involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane; modulation of chemical synaptic transmission; and vesicle-mediated transport in synapse. Acts upstream of or within exocytosis and long-term synaptic potentiation. Located in several cellular components, including cytoplasmic vesicle; photoreceptor inner segment; and photoreceptor outer segment. Part of SNARE complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human STX3 (syntaxin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in placenta adult (RPKM 14.0), cerebellum adult (RPKM 6.3) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 8.52 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (11752482..11798933, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (11775118..11821569, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syntaxin 3 SPI-2 dependent crosstalk facilitates the division of Salmonella containing vacuole.
Title: Syntaxin 3 SPI-2 dependent crosstalk facilitates the division of Salmonella containing vacuole.
Syntaxin 3 is essential for photoreceptor outer segment protein trafficking and survival.
Title: Syntaxin 3 is essential for photoreceptor outer segment protein trafficking and survival.
the residual exocytic function of Stx3-deficient MCs was sufficient to drive a full anaphylactic response in mice
Title: Syntaxin 3, but not syntaxin 4, is required for mast cell-regulated exocytosis, where it plays a primary role mediating compound exocytosis.
Rab11a-knockdown cells displayed mislocalization of STX3 and the presentation of microvilli in the basolateral compartment
Title: Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes.
Phosphorylation of syntaxin 3B by CaMKII can modulate the assembly of the SNARE complex in ribbon synapses of the retina.
Title: Phosphorylation of syntaxin 3B by CaMKII regulates the formation of t-SNARE complexes.
The SNARE machinery composed of VAMP7 on Tyrp1-containing vesicles and syntaxin-3 and SNAP23 on melanosomes regulates Tyrp1 trafficking to the melanosome in melanocytes.
Title: Syntaxin-3 is required for melanosomal localization of Tyrp1 in melanocytes.
In insulin secretion, SYN-3 plays a role in the mediation of newcomer SG exocytosis and SG-SG fusion that contributes to biphasic GSIS.
Title: Syntaxin-3 regulates newcomer insulin granule exocytosis and compound fusion in pancreatic beta cells.
Results show that cells in the mouse retina express only syntaxin 3B, while nonneuronal tissues, such as kidney, express only syntaxin 3A.
Title: Syntaxin 3b is a t-SNARE specific for ribbon synapses of the retina.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (3) 1 citation
Targeted (2)
Transposon induced (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA960228 (e-PCR)
- UniSTS:160802

AV006285 (e-PCR)
- UniSTS:166130

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNAP receptor activity	ISO Inferred from Sequence Orthology more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	EXP Inferred from Experiment more info	PubMed
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane fusion	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in organelle membrane fusion	ISO Inferred from Sequence Orthology more info
involved_in organelle membrane fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport in synapse	EXP Inferred from Experiment more info	PubMed
involved_in vesicle-mediated transport in synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport in synapse	IEP Inferred from Expression Pattern more info	PubMed
involved_in vesicle-mediated transport in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IDA Inferred from Direct Assay more info	PubMed
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in azurophil granule	IEA Inferred from Electronic Annotation more info
located_in azurophil granule	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in melanosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IMP Inferred from Mutant Phenotype more info	PubMed
located_in photoreceptor outer segment	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in specific granule	IEA Inferred from Electronic Annotation more info
located_in specific granule	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in zymogen granule membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in zymogen granule membrane	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: syntaxin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025307.2 → NP_001020478.1 syntaxin-3 isoform B

See identical proteins and their annotated locations for NP_001020478.1

Status: VALIDATED

Source sequence(s)

BC024844, BC056949, BM936677

Consensus CDS

CCDS29611.1

UniProtKB/TrEMBL

Q8CAN1

Related

ENSMUSP00000074776.8, ENSMUST00000075304.14

Conserved Domains (2) summary

pfam00804
Location:32 → 226

Syntaxin

cl22856
Location:194 → 260

SNARE; SNARE motif
NM_001286543.2 → NP_001273472.1 syntaxin-3 isoform D

See identical proteins and their annotated locations for NP_001273472.1

Status: VALIDATED

Source sequence(s)

AC126266, BC024844, BC056949

UniProtKB/Swiss-Prot

Q64704

Conserved Domains (2) summary

pfam00804
Location:1 → 129

Syntaxin

cl22856
Location:97 → 163

SNARE; SNARE motif
NM_001360386.1 → NP_001347315.1 syntaxin-3 isoform D

Status: VALIDATED

Source sequence(s)

AC126036, AC126266

Conserved Domains (2) summary

pfam00804
Location:1 → 129

Syntaxin

cl22856
Location:97 → 163

SNARE; SNARE motif
NM_011502.4 → NP_035632.1 syntaxin-3 isoform C

See identical proteins and their annotated locations for NP_035632.1

Status: VALIDATED

Source sequence(s)

AC126266, BC024844, BC056949

Consensus CDS

CCDS29612.1

UniProtKB/TrEMBL

Q8CAN1

Related

ENSMUSP00000147398.2, ENSMUST00000211641.2

Conserved Domains (2) summary

pfam00804
Location:49 → 208

Syntaxin; Syntaxin

cl22856
Location:176 → 242

SNARE; SNARE motif
NM_152220.2 → NP_689344.1 syntaxin-3 isoform A

See identical proteins and their annotated locations for NP_689344.1

Status: VALIDATED

Source sequence(s)

AC126266, AK133830, BC056949, BF318335, BG064925, BG079344, BX634318, CJ058200

Consensus CDS

CCDS29613.1

UniProtKB/Swiss-Prot

Q3TBP0, Q64704, Q8R1B7

UniProtKB/TrEMBL

Q3UZI9

Related

ENSMUSP00000069529.5, ENSMUST00000069285.6

Conserved Domains (2) summary

pfam00804
Location:32 → 226

Syntaxin

cl22856
Location:194 → 260

SNARE; SNARE motif

RNA

NR_153433.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC126036, AC126266
NR_153434.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC126036, AC126266

Related

ENSMUST00000047698.14

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

11752482..11798933 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161504.1 → XP_036017397.1 syntaxin-3 isoform X2

Conserved Domains (2) summary

pfam00804
Location:1 → 129

Syntaxin

cl22856
Location:97 → 163

SNARE; SNARE motif
XM_036161503.1 → XP_036017396.1 syntaxin-3 isoform X2

Conserved Domains (2) summary

pfam00804
Location:1 → 129

Syntaxin

cl22856
Location:97 → 163

SNARE; SNARE motif
XM_006526844.4 → XP_006526907.1 syntaxin-3 isoform X1

UniProtKB/TrEMBL

Q8CAN1

Conserved Domains (2) summary

pfam00804
Location:32 → 226

Syntaxin

cl22856
Location:194 → 260

SNARE; SNARE motif

RNA

XR_001782567.2 RNA Sequence
XR_001782569.2 RNA Sequence
XR_001782568.2 RNA Sequence
XR_004940132.1 RNA Sequence
XR_003952772.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001025308.1: Suppressed sequence

Description

NM_001025308.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.