Eif5a eukaryotic translation initiation factor 5A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif5aprovided by MGI
Official Full Name: eukaryotic translation initiation factor 5Aprovided by MGI
Primary source: MGI:MGI:106248
See related: Ensembl:ENSMUSG00000078812 AllianceGenome:MGI:106248
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eif4d; Eif5a1; eIF-4D; eIF-5A; eIF-5A1; eIF-5A-1; D19Wsu54e
Summary: This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]
Expression: Ubiquitous expression in liver E14 (RPKM 325.9), liver E14.5 (RPKM 312.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.92 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69807538..69812784, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69916712..69921958, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
Title: Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
Targeted inhibition of eIF5A[hpu] suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
Title: Targeted inhibition of eIF5A(hpu) suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
Title: Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
Title: Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
Title: Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
The eIF5A (eIF5A(H)) promotes the efficient expression of a subset of mitochondrial proteins involved in the TCA cycle and oxidative phosphorylation (OXPHOS).
Title: Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.
Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
Title: Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
our results provide the first genetic evidence that the hypusine modification in eIF-5A is crucial for homeostasis in mammals
Title: Biological Relevance and Therapeutic Potential of the Hypusine Modification System.
knockout of either the eIF5A-1 gene (Eif5a) or of the deoxyhypusine synthase gene (Dhps) caused early embryonic lethality in mice, indicating the essential nature of both eIF5A-1 and deoxyhypusine synthase in mammalian development
Title: Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.
These results point to a new functional role for eIF5A, relating it to embryogenesis, development, and cell differentiation.
Title: Evidences of a role for eukaryotic translation initiation factor 5A (eIF5A) in mouse embryogenesis and cell differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI505953 (e-PCR)
- UniSTS:180235

RH125923 (e-PCR)
- UniSTS:162640

RH126545 (e-PCR)
- UniSTS:142225

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables U6 snRNA binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translational elongation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational termination	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in annulate lamellae	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 5A-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166589.1 → NP_001160061.1 eukaryotic translation initiation factor 5A-1

See identical proteins and their annotated locations for NP_001160061.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also referred to as variant BD) represents the longest transcript. Variants 1-9 encode the same protein.

Source sequence(s)

AI850684, AK010183, AK011306, AK218644, AL596185, CX237346

Consensus CDS

CCDS24923.1

UniProtKB/Swiss-Prot

P63242, Q5NCX0, Q78NR3

UniProtKB/TrEMBL

A0A0A0MQM0

Related

ENSMUSP00000047008.4, ENSMUST00000043419.10

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
NM_001166590.1 → NP_001160062.1 eukaryotic translation initiation factor 5A-1

See identical proteins and their annotated locations for NP_001160062.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also referred to as variant D) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.

Source sequence(s)

AI850684, AK011306, AK218644, AL596185, CX237346

Consensus CDS

CCDS24923.1

UniProtKB/Swiss-Prot

P63242, Q5NCX0, Q78NR3

UniProtKB/TrEMBL

A0A0A0MQM0

Related

ENSMUSP00000104250.2, ENSMUST00000108610.8

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
NM_001166591.1 → NP_001160063.1 eukaryotic translation initiation factor 5A-1

See identical proteins and their annotated locations for NP_001160063.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, also referred to as variant BE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.

Source sequence(s)

AI850684, AK010183, AK011306, AK218644, AL596185

Consensus CDS

CCDS24923.1

UniProtKB/Swiss-Prot

P63242, Q5NCX0, Q78NR3

UniProtKB/TrEMBL

A0A0A0MQM0

Related

ENSMUSP00000067077.5, ENSMUST00000070996.11

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
NM_001166592.1 → NP_001160064.1 eukaryotic translation initiation factor 5A-1

See identical proteins and their annotated locations for NP_001160064.1

Status: REVIEWED

Description

Transcript Variant: This variant (4, also referred to as variant CD) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.

Source sequence(s)

AI850684, AK011306, AK218644, CX218195, CX237346

Consensus CDS

CCDS24923.1

UniProtKB/Swiss-Prot

P63242, Q5NCX0, Q78NR3

UniProtKB/TrEMBL

A0A0A0MQM0

Related

ENSMUSP00000104251.2, ENSMUST00000108611.8

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
NM_001166593.1 → NP_001160065.1 eukaryotic translation initiation factor 5A-1

See identical proteins and their annotated locations for NP_001160065.1

Status: REVIEWED

Description

Transcript Variant: This variant (6, also referred to as variant AE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.

Source sequence(s)

AI850684, AK011306, AK218644, AL596185

Consensus CDS

CCDS24923.1

UniProtKB/Swiss-Prot

P63242, Q5NCX0, Q78NR3

UniProtKB/TrEMBL

A0A0A0MQM0

Related

ENSMUSP00000068651.4, ENSMUST00000071026.10

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
NM_001166594.1 → NP_001160066.1 eukaryotic translation initiation factor 5A-1

See identical proteins and their annotated locations for NP_001160066.1

Status: REVIEWED

Description

Transcript Variant: This variant (7, also referred to as variant C) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.

Source sequence(s)

AI850684, AK011306, AK218644, CX218195, CX237346

Consensus CDS

CCDS24923.1

UniProtKB/Swiss-Prot

P63242, Q5NCX0, Q78NR3

UniProtKB/TrEMBL

A0A0A0MQM0

Related

ENSMUSP00000104252.2, ENSMUST00000108612.8

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
NM_001166595.1 → NP_001160067.1 eukaryotic translation initiation factor 5A-1

See identical proteins and their annotated locations for NP_001160067.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.

Source sequence(s)

AI850684, AK011306, AK218644, AL596185

Consensus CDS

CCDS24923.1

UniProtKB/Swiss-Prot

P63242, Q5NCX0, Q78NR3

UniProtKB/TrEMBL

A0A0A0MQM0

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
NM_001166596.1 → NP_001160068.1 eukaryotic translation initiation factor 5A-1

See identical proteins and their annotated locations for NP_001160068.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.

Source sequence(s)

AI850684, AK011306, AK218644, AL596185, CX237346

Consensus CDS

CCDS24923.1

UniProtKB/Swiss-Prot

P63242, Q5NCX0, Q78NR3

UniProtKB/TrEMBL

A0A0A0MQM0

Related

ENSMUSP00000132717.2, ENSMUST00000164359.8

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
NM_181582.4 → NP_853613.1 eukaryotic translation initiation factor 5A-1

See identical proteins and their annotated locations for NP_853613.1

Status: REVIEWED

Description

Transcript Variant: This variant (5, also referred to as variant B) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.

Source sequence(s)

AI850684, AK010183, AK011306, AK218644, AL596185

Consensus CDS

CCDS24923.1

UniProtKB/Swiss-Prot

P63242, Q5NCX0, Q78NR3

UniProtKB/TrEMBL

A0A0A0MQM0

Related

ENSMUSP00000104253.4, ENSMUST00000108613.10

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69807538..69812784 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246050.2 → XP_030101910.1 eukaryotic translation initiation factor 5A-1 isoform X1

UniProtKB/Swiss-Prot

P63242, Q5NCX0, Q78NR3

UniProtKB/TrEMBL

A0A0A0MQM0

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
XM_011249058.4 → XP_011247360.1 eukaryotic translation initiation factor 5A-1 isoform X1

See identical proteins and their annotated locations for XP_011247360.1

UniProtKB/Swiss-Prot

P63242, Q5NCX0, Q78NR3

UniProtKB/TrEMBL

A0A0A0MQM0

Related

ENSMUSP00000104249.2, ENSMUST00000108609.8

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
XM_030246051.1 → XP_030101911.1 eukaryotic translation initiation factor 5A-1 isoform X1

UniProtKB/Swiss-Prot

P63242, Q5NCX0, Q78NR3

UniProtKB/TrEMBL

A0A0A0MQM0

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
XM_036156739.1 → XP_036012632.1 eukaryotic translation initiation factor 5A-1 isoform X1

UniProtKB/Swiss-Prot

P63242, Q5NCX0, Q78NR3

UniProtKB/TrEMBL

A0A0A0MQM0

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional