ncs1.L neuronal calcium sensor 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ncs1.L
Official Full Name: neuronal calcium sensor 1 L homeolog
Primary source: Xenbase:XB-GENE-953746
Locus tag: XELAEV_18003338mg
See related: EnsemblRapid:ENSXLAG00005022208 AllianceGenome:Xenbase:XB-GENE-953746
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: flup; freq; ncs1; xfreq
Summary: Predicted to enable voltage-gated calcium channel activity. Predicted to act upstream of or within regulation of neuron projection development. Predicted to be located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and postsynaptic density. Is expressed in nervous system. Orthologous to human NCS1 (neuronal calcium sensor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8L

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (9133411..9167247, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694837.1 (661179..695412)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium sensitive guanylate cyclase activator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuronal calcium sensor 1

Names: NCS-1; frequenin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090619.1 → NP_001084088.1 neuronal calcium sensor 1

See identical proteins and their annotated locations for NP_001084088.1

Status: PROVISIONAL

Source sequence(s)

BC072752

UniProtKB/Swiss-Prot

Q6GQJ0, Q91614

Related

ENSXLAP00005065349.1, ENSXLAT00005066865.1

Conserved Domains (2) summary

COG5126
Location:20 → 179

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:100 → 172

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...