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    ppip5k2.L diphosphoinositol pentakisphosphate kinase 2 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 495012, updated on 4-Nov-2024

    Summary

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    Official Symbol
    ppip5k2.L
    Official Full Name
    diphosphoinositol pentakisphosphate kinase 2 L homeolog
    Primary source
    Xenbase:XB-GENE-1000382
    Locus tag
    XELAEV_18008035mg
    See related
    EnsemblRapid:ENSXLAG00005033025 AllianceGenome:Xenbase:XB-GENE-1000382
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    vip2; ip7k2; hisppd1; ppip5k2
    Summary
    Predicted to enable ATP binding activity and inositol phosphate kinase activity. Predicted to act upstream of or within inositol metabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 100. Orthologous to human PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ppip5k2.L in Genome Data Viewer
    Location:
    chromosome: 1L
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (190577165..190646638, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (177422026..177491760, complement)

    Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108695678 Neighboring gene macrophage immunometabolism regulator L homeolog Neighboring gene peptidylglycine alpha-amidating monooxygenase L homeolog Neighboring gene uncharacterized LOC121395337

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables diphosphoinositol pentakisphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol hexakisphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within inositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inositol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within inositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
    Names
    VIP1 homolog 2
    histidine acid phosphatase domain-containing protein 1
    insP6 and PP-IP5 kinase 2
    XP_018103775.1
    XP_018103787.1
    XP_018103790.1
    XP_018103796.1
    XP_018103803.1
    XP_018103808.1
    XP_018103814.1
    XP_041424315.1
    XP_041424319.1
    XP_041424328.1
    XP_041424334.1
    XP_041424336.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      190577165..190646638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018248286.2 → XP_018103775.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5XHF8
      UniProtKB/TrEMBL
      A0A8J0UA90
      Related
      ENSXLAP00005099641.1, ENSXLAT00005101557.1

    2. XM_041568385.1 → XP_041424319.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X6

      UniProtKB/Swiss-Prot
      Q5XHF8
      UniProtKB/TrEMBL
      A0A8J1L5U8
      Conserved Domains (2) summary
      cd07061
      Location:468 → 847
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
      cl00913
      Location:608 → 731
      CbiC; Precorrin-8X methylmutase

    3. XM_018248301.2 → XP_018103790.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X4

      UniProtKB/Swiss-Prot
      Q5XHF8
      UniProtKB/TrEMBL
      A0A8J0UI98
      Related
      ENSXLAP00005100297.1, ENSXLAT00005102252.1

    4. XM_018248298.2 → XP_018103787.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X2

      UniProtKB/Swiss-Prot
      Q5XHF8
      UniProtKB/TrEMBL
      A0A8J0UA96

    5. XM_041568381.1 → XP_041424315.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X3

      UniProtKB/Swiss-Prot
      Q5XHF8
      UniProtKB/TrEMBL
      A0A8J1L6U8
      Related
      ENSXLAP00005099756.1, ENSXLAT00005101683.1
      Conserved Domains (2) summary
      cd07061
      Location:527 → 906
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
      cl00913
      Location:667 → 790
      CbiC; Precorrin-8X methylmutase

    6. XM_018248319.2 → XP_018103808.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X9

      UniProtKB/Swiss-Prot
      Q5XHF8
      UniProtKB/TrEMBL
      A0A8J0UAB3
      Related
      ENSXLAP00005100182.1, ENSXLAT00005102137.1

    7. XM_018248325.2 → XP_018103814.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12

      UniProtKB/Swiss-Prot
      Q5XHF8
      UniProtKB/TrEMBL
      A0A8J0UAB8
      Related
      ENSXLAP00005100094.1, ENSXLAT00005102046.1

    8. XM_018248307.2 → XP_018103796.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X5

      UniProtKB/Swiss-Prot
      Q5XHF8
      UniProtKB/TrEMBL
      A0A8J0UIA3
      Related
      ENSXLAP00005099978.1, ENSXLAT00005101928.1

    9. XM_041568394.1 → XP_041424328.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X8

      UniProtKB/Swiss-Prot
      Q5XHF8
      UniProtKB/TrEMBL
      A0A8J1L477
      Conserved Domains (2) summary
      cd07061
      Location:527 → 906
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
      cl00913
      Location:667 → 790
      CbiC; Precorrin-8X methylmutase

    10. XM_018248314.2 → XP_018103803.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X7

      UniProtKB/Swiss-Prot
      Q5XHF8
      UniProtKB/TrEMBL
      A0A1L8I1P6, A0A974I5R3
      Related
      ENSXLAP00005099408.1, ENSXLAT00005101301.1

    11. XM_041568400.1 → XP_041424334.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X10

      UniProtKB/Swiss-Prot
      Q5XHF8
      UniProtKB/TrEMBL
      A0A8J1L5W2
      Related
      ENSXLAP00005100402.1, ENSXLAT00005102359.1
      Conserved Domains (2) summary
      cd07061
      Location:527 → 906
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
      cl00913
      Location:667 → 790
      CbiC; Precorrin-8X methylmutase

    12. XM_041568402.1 → XP_041424336.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X11

      UniProtKB/Swiss-Prot
      Q5XHF8
      UniProtKB/TrEMBL
      A0A8J1L462
      Conserved Domains (2) summary
      cd07061
      Location:367 → 746
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
      cl00913
      Location:507 → 630
      CbiC; Precorrin-8X methylmutase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001094718.1: Suppressed sequence

      Description
      NM_001094718.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XHF8.1 GenPept UniProtKB/Swiss-Prot:Q5XHF8

    Gene LinkOut

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