Wfdc2 WAP four-disulfide core domain 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wfdc2provided by MGI
Official Full Name: WAP four-disulfide core domain 2provided by MGI
Primary source: MGI:MGI:1914951
See related: Ensembl:ENSMUSG00000017723 AllianceGenome:MGI:1914951
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HE4; WAP5; 1600023A02Rik
Summary: Predicted to enable aspartic-type endopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; liver; and retina. Orthologous to human WFDC2 (WAP four-disulfide core domain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 444.2), bladder adult (RPKM 229.1) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 85.2 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164404635..164410430)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164562715..164568510)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of HE4 suppresses tumor growth and invasiveness in lung adenocarcinoma through regulation of EGFR signaling.
Title: Knockdown of HE4 suppresses tumor growth and invasiveness in lung adenocarcinoma through regulation of EGFR signaling.
HE4 overexpression in mice leads to leydig cell hyperplasia and spermatogensis impairment: Pathological implications for oligospermia.
Title: HE4 overexpression in mice leads to leydig cell hyperplasia and spermatogensis impairment: Pathological implications for oligospermia.
WFDC2 Promotes Spasmolytic Polypeptide-Expressing Metaplasia Through the Up-Regulation of IL33 in Response to Injury.
Title: WFDC2 Promotes Spasmolytic Polypeptide-Expressing Metaplasia Through the Up-Regulation of IL33 in Response to Injury.
WFDC2 suppresses prostate cancer metastasis by modulating EGFR signaling inactivation.
Title: WFDC2 suppresses prostate cancer metastasis by modulating EGFR signaling inactivation.
WFDC2 gene deletion in mouse led to severe dyspnea and type-I alveolar cell apoptosis.
Title: WFDC2 gene deletion in mouse led to severe dyspnea and type-I alveolar cell apoptosis.
Wfdc2 function is vitally important for lung aeration at birth and that gene deficiency likely causes failure of the lung mucosal barrier.
Title: Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice.
Causal testing implicates Wfdc2 and Hdac3 as novel genes affecting high density lipoprotein levels
Title: A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Gene trapped (1)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables aspartic-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WAP four-disulfide core domain protein 2

Names: WAP domain-containing protein HE4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374655.1 → NP_001361584.1 WAP four-disulfide core domain protein 2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL591478

Consensus CDS

CCDS89579.1

UniProtKB/TrEMBL

A2A5G5

Related

ENSMUSP00000104969.3, ENSMUST00000109345.9

Conserved Domains (2) summary

cd00199
Location:61 → 121

WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...

pfam00095
Location:32 → 73

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
NM_026323.2 → NP_080599.1 WAP four-disulfide core domain protein 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_080599.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK005519

Consensus CDS

CCDS17040.1

UniProtKB/Swiss-Prot

Q9DAU7

UniProtKB/TrEMBL

Q4FZJ6

Related

ENSMUSP00000017867.4, ENSMUST00000017867.10

Conserved Domains (2) summary

cd00199
Location:127 → 173

WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...

pfam00095
Location:32 → 73

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'