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    Arhgap26 Rho GTPase activating protein 26 [ Mus musculus (house mouse) ]

    Gene ID: 71302, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Arhgap26provided by MGI
    Official Full Name
    Rho GTPase activating protein 26provided by MGI
    Primary source
    MGI:MGI:1918552
    See related
    Ensembl:ENSMUSG00000036452 AllianceGenome:MGI:1918552
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0621; 1810044B20Rik; 2610010G17Rik; 4933432P15Rik
    Summary
    Predicted to enable GTPase activator activity; phospholipid binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in mitophagy. Predicted to be located in cytosol and endosome membrane. Predicted to be active in mitochondrion. Is expressed in amygdala; diencephalon lateral wall mantle layer; hypothalamus mantle layer; olfactory epithelium; and telencephalon mantle layer. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia and juvenile myelomonocytic leukemia. Orthologous to human ARHGAP26 (Rho GTPase activating protein 26). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 9.3), cortex adult (RPKM 5.9) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgap26 in Genome Data Viewer
    Location:
    18 B3; 18 20.51 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (38734531..39509338)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (38601617..39376285)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44374 Neighboring gene STARR-seq mESC enhancer starr_44375 Neighboring gene STARR-seq mESC enhancer starr_44376 Neighboring gene STARR-seq mESC enhancer starr_44377 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene Neighboring gene sprouty RTK signaling antagonist 4 Neighboring gene predicted gene, 19774 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44384 Neighboring gene STARR-seq mESC enhancer starr_44387 Neighboring gene fibroblast growth factor 1 Neighboring gene STARR-seq mESC enhancer starr_44390 Neighboring gene predicted gene 5820 Neighboring gene STARR-positive B cell enhancer ABC_E10987 Neighboring gene STARR-positive B cell enhancer ABC_E4246 Neighboring gene predicted gene, 52330 Neighboring gene STARR-seq mESC enhancer starr_44392 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:39242828-39243011 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:39243680-39243789 Neighboring gene STARR-seq mESC enhancer starr_44393 Neighboring gene STARR-seq mESC enhancer starr_44394 Neighboring gene STARR-seq mESC enhancer starr_44395 Neighboring gene STARR-seq mESC enhancer starr_44397 Neighboring gene STARR-seq mESC enhancer starr_44398 Neighboring gene STARR-seq mESC enhancer starr_44400 Neighboring gene STARR-seq mESC enhancer starr_44401 Neighboring gene predicted gene 15337 Neighboring gene predicted gene, 57770 Neighboring gene STARR-positive B cell enhancer ABC_E10988 Neighboring gene STARR-positive B cell enhancer ABC_E10989 Neighboring gene nuclear receptor subfamily 3, group C, member 1 Neighboring gene predicted gene, 54019

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GRAF1 promotes ferlin-dependent myoblast fusion. Lenhart KC, et al. Dev Biol, 2014 Sep 15. PMID 25019370, Free PMC Article
    2. ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility. Zhu Q, et al. Autophagy, 2024 Aug. PMID 38855880,
    3. GRAF1 deficiency blunts sarcolemmal injury repair and exacerbates cardiac and skeletal muscle pathology in dystrophin-deficient mice. Lenhart KC, et al. Skelet Muscle, 2015. PMID 26301073, Free PMC Article
    4. Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss. Lee S, et al. J Neurosci, 2019 Mar 6. PMID 30626696, Free PMC Article
    5. GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis. Zhu Q, et al. Nat Commun, 2023 Dec 11. PMID 38081847, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility.
      Title: ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility.
    2. GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
      Title: GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
    3. Study shows that brain Pyk2 interacts with the RhoGAP protein Graf1 to alter dendritic spine stability via RhoA GTPase. Amyloid-beta oligomer-induced dendritic spine loss requires the Pyk2/Graf1 pathway.
      Title: Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss.
    4. GRAF1 and 2 facilitate myoblast fusion, at least in part, by promoting vesicle-mediated translocation of fusogenic ferlin proteins to the plasma membrane.
      Title: GRAF1 promotes ferlin-dependent myoblast fusion.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 26
    Names
    rho-type GTPase-activating protein 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361073.1 → NP_001348002.1  rho GTPase-activating protein 26 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorterC, compared to isoform 1.
      Source sequence(s)
      AC110730, AC129603, AC132450
      Consensus CDS
      CCDS89227.1
      UniProtKB/TrEMBL
      B9EJ96, F6T836
      Related
      ENSMUSP00000121197.3, ENSMUST00000137497.9
      Conserved Domains (4) summary
      cd07636
      Location:19 → 225
      BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
      cd12064
      Location:667 → 722
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

    2. NM_001374831.1 → NP_001361760.1  rho GTPase-activating protein 26 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC110730, AC129603, AC132450
      Consensus CDS
      CCDS89226.1
      UniProtKB/TrEMBL
      B9EJ96, E9QAQ3
      Related
      ENSMUSP00000122371.2, ENSMUST00000155576.8
      Conserved Domains (4) summary
      cd07636
      Location:19 → 225
      BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
      cd12064
      Location:704 → 759
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

    3. NM_175164.4 → NP_780373.3  rho GTPase-activating protein 26 isoform 1

      See identical proteins and their annotated locations for NP_780373.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC007995, AK011368, AK129176, AK152368, BM935209
      Consensus CDS
      CCDS29205.1
      UniProtKB/Swiss-Prot
      E9QLL3, Q6ZQ82
      UniProtKB/TrEMBL
      B9EJ96
      Related
      ENSMUSP00000095200.3, ENSMUST00000097593.9
      Conserved Domains (5) summary
      cd07636
      Location:19 → 225
      BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
      cd12064
      Location:759 → 814
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 364
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      38734531..39509338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161285.1 → XP_036017178.1  rho GTPase-activating protein 26 isoform X4

      UniProtKB/TrEMBL
      B9EJ96
      Conserved Domains (4) summary
      cd12064
      Location:676 → 731
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:373 → 572
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:276 → 380
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:61 → 234
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_030250607.2 → XP_030106467.1  rho GTPase-activating protein 26 isoform X2

      UniProtKB/TrEMBL
      B9EJ96
      Conserved Domains (4) summary
      cd12064
      Location:757 → 812
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:362 → 561
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:265 → 369
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:50 → 223
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_036161286.1 → XP_036017179.1  rho GTPase-activating protein 26 isoform X5

      UniProtKB/TrEMBL
      B9EJ96
      Conserved Domains (4) summary
      cd12064
      Location:665 → 720
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:362 → 561
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:265 → 369
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:50 → 223
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_017317984.2 → XP_017173473.2  rho GTPase-activating protein 26 isoform X2

      UniProtKB/TrEMBL
      B9EJ96
      Conserved Domains (4) summary
      cd12064
      Location:757 → 812
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:362 → 561
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:265 → 369
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:50 → 223
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_036161284.1 → XP_036017177.1  rho GTPase-activating protein 26 isoform X1

      UniProtKB/TrEMBL
      B9EJ96
      Conserved Domains (4) summary
      cd12064
      Location:768 → 823
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:373 → 572
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:276 → 380
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:61 → 234
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_006526267.4 → XP_006526330.1  rho GTPase-activating protein 26 isoform X3

      UniProtKB/TrEMBL
      B9EJ96
      Conserved Domains (4) summary
      cd07636
      Location:19 → 225
      BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
      cd12064
      Location:714 → 769
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

    7. XM_036161288.1 → XP_036017181.1  rho GTPase-activating protein 26 isoform X8

      UniProtKB/TrEMBL
      B9EJ96
      Conserved Domains (4) summary
      cd07636
      Location:19 → 225
      BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl17036
      Location:714 → 740
      SH3; Src Homology 3 domain superfamily

    8. XM_030250608.2 → XP_030106468.1  rho GTPase-activating protein 26 isoform X7

      UniProtKB/TrEMBL
      B9EJ96
      Conserved Domains (3) summary
      cd07636
      Location:19 → 225
      BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

    9. XM_036161287.1 → XP_036017180.1  rho GTPase-activating protein 26 isoform X6

      UniProtKB/TrEMBL
      B9EJ96
      Conserved Domains (4) summary
      cd12064
      Location:634 → 689
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:284 → 483
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:187 → 291
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:1 → 145
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQ82.3 GenPept UniProtKB/Swiss-Prot:Q6ZQ82

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