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    Grm7 glutamate receptor, metabotropic 7 [ Mus musculus (house mouse) ]

    Gene ID: 108073, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Grm7provided by MGI
    Official Full Name
    glutamate receptor, metabotropic 7provided by MGI
    Primary source
    MGI:MGI:1351344
    See related
    Ensembl:ENSMUSG00000056755 AllianceGenome:MGI:1351344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SMN2; Gpr1g; Gprc1g; mGluR7; C030018L03; 6330570A01Rik; E130018M02Rik; Tg(SMN2)89Ahmb
    Summary
    Enables calcium channel regulator activity and voltage-gated calcium channel activity. Involved in chemical synaptic transmission and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and transmission of nerve impulse. Located in presynaptic membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; eye; reproductive system; and spinal cord. Used to study Werdnig-Hoffmann disease. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 6.5), frontal lobe adult (RPKM 4.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Grm7 in Genome Data Viewer
    Location:
    6 E3; 6 51.19 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (110622304..111544191)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (110645349..111567230)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35467 Neighboring gene STARR-seq mESC enhancer starr_16994 Neighboring gene STARR-seq mESC enhancer starr_16995 Neighboring gene STARR-seq mESC enhancer starr_16996 Neighboring gene STARR-seq mESC enhancer starr_16997 Neighboring gene D-tyrosyl-tRNA deacylase 1 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_16998 Neighboring gene STARR-seq mESC enhancer starr_16999 Neighboring gene predicted gene 20387 Neighboring gene STARR-seq mESC enhancer starr_17000 Neighboring gene STARR-seq mESC enhancer starr_17001 Neighboring gene STARR-seq mESC enhancer starr_17002 Neighboring gene STARR-seq mESC enhancer starr_17005 Neighboring gene STARR-seq mESC enhancer starr_17006 Neighboring gene STARR-seq mESC enhancer starr_17008 Neighboring gene STARR-seq mESC enhancer starr_17009 Neighboring gene STARR-seq mESC enhancer starr_17010 Neighboring gene RIKEN cDNA 1700054K19 gene Neighboring gene STARR-seq mESC enhancer starr_17012 Neighboring gene STARR-seq mESC enhancer starr_17013 Neighboring gene RIKEN cDNA 5031434C07 gene Neighboring gene STARR-seq mESC enhancer starr_17014 Neighboring gene LIM and cysteine-rich domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Presynaptic metabotropic glutamate receptors regulate glutamatergic input to dopamine neurons in the ventral tegmental area. de Rover M, et al. Neuroscience, 2008 Jul 17. PMID 18534761
    2. Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disorders. Mitsukawa K, et al. Neuropsychopharmacology, 2006 Jun. PMID 16237391
    3. Spinal Transection Switches the Effect of Metabotropic Glutamate Receptor Subtype 7 from the Facilitation to Inhibition of Ejaculation. Masugi-Tokita M, et al. Neuroscience, 2023 Jan 15. PMID 36403690
    4. Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. Gee CE, et al. J Biol Chem, 2014 Apr 18. PMID 24596089, Free PMC Article
    5. Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy. Avila AM, et al. J Clin Invest, 2007 Mar. PMID 17318264, Free PMC Article

    See all (304) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice.
      Title: PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice.
    2. A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses.
      Title: A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses.
    3. A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes.
      Title: A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes.
    4. Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders.
      Title: Phenotypic profiling of mGlu(7) knockout mice reveals new implications for neurodevelopmental disorders.
    5. Metabotropic Glutamate Receptor Subtype 7 Is Essential for Ejaculation.
      Title: Metabotropic Glutamate Receptor Subtype 7 Is Essential for Ejaculation.
    6. Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice.
      Title: Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice.
    7. A transsynaptic interaction between Elfn1 and mGluR7 constitutively reduces initial release probability onto mouse cortical SOM neurons. Elfn1 produces glutamate-independent activation of mGluR7 via presynaptic clustering, resulting in a divergence from the canonical "autoreceptor" role of Type III mGluRs, and substantially altering synaptic pharmacology.
      Title: Elfn1-Induced Constitutive Activation of mGluR7 Determines Frequency-Dependent Recruitment of Somatostatin Interneurons.
    8. mGlu7 is not functionally increased in mice overexpressing MeCP2 and that neither genetic nor pharmacological reduction of mGlu7 activity impacts phenotypes in a mouse model of MeCP2 duplication syndrome.
      Title: Genetic Reduction or Negative Modulation of mGlu(7) Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome.
    9. We found a significant reduction of testosterone levels in mGluR7 knockout (KO) mice. Social investigating behaviour of intact mGluR7 KO mice also differed from that of wild-type mice; e.g. the KO mice showing less frequent anogenital sniffing and more frequent grooming behaviour. Further, castrated mGluR7 KO mice have smaller seminal vesicles than those of castrated wild-type mice, although intact mice were no different.
      Title: Metabotropic glutamate receptor subtype 7 has critical roles in regulation of the endocrine system and social behaviours.
    10. Altered mGlu7 expression was found in brain regions associated with fear extinction in two different mouse strains which differ in their fear extinction behavior.
      Title: Increased amygdalar metabotropic glutamate receptor 7 mRNA in a genetic mouse model of impaired fear extinction.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90857

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables PDZ domain binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenylate cyclase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutamate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables group III metabotropic glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables group III metabotropic glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables group III metabotropic glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables group III metabotropic glutamate receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within associative learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axon development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within conditioned taste aversion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organismal response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nervous system process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transmission of nerve impulse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic active zone membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metabotropic glutamate receptor 7
    Names
    G protein-coupled receptor GRM7
    G protein-coupled receptor, family C, group 1, member G
    mGlu7a receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346640.1 → NP_001333569.1  metabotropic glutamate receptor 7 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC114643, AC125046, AC132394, AC142264, AC169981, AC169984
      Consensus CDS
      CCDS85110.1
      UniProtKB/TrEMBL
      G5E8D5
      Related
      ENSMUSP00000064404.7, ENSMUST00000071076.13
      Conserved Domains (3) summary
      cd15451
      Location:589 → 895
      7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06376
      Location:43 → 511
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
      pfam07562
      Location:519 → 569
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    2. NM_177328.3 → NP_796302.2  metabotropic glutamate receptor 7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_796302.2

      Status: VALIDATED

      Source sequence(s)
      AC114643, AC125046, AC132394, AC142264, AC169981, AC169984
      Consensus CDS
      CCDS39587.1
      UniProtKB/Swiss-Prot
      Q68ED2
      Related
      ENSMUSP00000133957.2, ENSMUST00000172951.2
      Conserved Domains (3) summary
      cd15451
      Location:589 → 895
      7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06376
      Location:43 → 511
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
      pfam07562
      Location:519 → 569
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      110622304..111544191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505296.3 → XP_006505359.1  metabotropic glutamate receptor 7 isoform X1

      Conserved Domains (3) summary
      cd15451
      Location:589 → 895
      7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:519 → 569
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06376
      Location:43 → 511
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

    2. XM_017321298.3 → XP_017176787.1  metabotropic glutamate receptor 7 isoform X1

      Conserved Domains (3) summary
      cd15451
      Location:589 → 895
      7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:519 → 569
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06376
      Location:43 → 511
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

    3. XM_006505298.4 → XP_006505361.1  metabotropic glutamate receptor 7 isoform X2

      See identical proteins and their annotated locations for XP_006505361.1

      UniProtKB/TrEMBL
      G5E8D5
      Conserved Domains (3) summary
      cd15451
      Location:589 → 895
      7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06376
      Location:43 → 511
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
      pfam07562
      Location:519 → 569
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    4. XM_006505301.3 → XP_006505364.1  metabotropic glutamate receptor 7 isoform X4

      Conserved Domains (3) summary
      cd15451
      Location:589 → 895
      7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:519 → 569
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06376
      Location:43 → 511
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

    5. XM_006505300.4 → XP_006505363.1  metabotropic glutamate receptor 7 isoform X3

      Conserved Domains (3) summary
      cd15451
      Location:589 → 895
      7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:519 → 569
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06376
      Location:43 → 511
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

    6. XM_006505302.4 → XP_006505365.1  metabotropic glutamate receptor 7 isoform X5

      Conserved Domains (3) summary
      cd15286
      Location:589 → 817
      7tmC_mGluR_group3; metabotropic glutamate receptors in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:519 → 569
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06376
      Location:43 → 511
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

    RNA

    1. XR_003956139.2 RNA Sequence

    2. XR_003956140.2 RNA Sequence

    3. XR_003956142.2 RNA Sequence

    4. XR_003956141.2 RNA Sequence

    5. XR_004942887.1 RNA Sequence

    6. XR_001785078.3 RNA Sequence

    7. XR_001785080.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177970.1: Suppressed sequence

      Description
      NM_177970.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68ED2.1 GenPept UniProtKB/Swiss-Prot:Q68ED2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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