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    Cgrrf1 cell growth regulator with ring finger domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 68755, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cgrrf1provided by MGI
    Official Full Name
    cell growth regulator with ring finger domain 1provided by MGI
    Primary source
    MGI:MGI:1916368
    See related
    Ensembl:ENSMUSG00000055128 AllianceGenome:MGI:1916368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGR19; 1110038G02Rik; 1810009H17Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of cell growth. Predicted to be located in endoplasmic reticulum and nucleoplasm. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human CGRRF1 (cell growth regulator with ring finger domain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.6), bladder adult (RPKM 15.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cgrrf1 in Genome Data Viewer
    Location:
    14 C1; 14 24.34 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47069591..47091655)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (46832134..46854198)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene cornichon family AMPA receptor auxiliary protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7306 Neighboring gene STARR-positive B cell enhancer ABC_E5430 Neighboring gene glia maturation factor, beta Neighboring gene predicted gene, 34934 Neighboring gene sterile alpha motif domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_36564 Neighboring gene predicted gene, 52120 Neighboring gene microRNA 378c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Long Non-coding RNA 4933425B07Rik Causes Urinary Malformations in Mice. Tan L, et al. Front Cell Dev Biol, 2021. PMID 33681192, Free PMC Article
    2. Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles. L'Hôte D, et al. Hum Mol Genet, 2012 Jul 15. PMID 22544055
    3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell growth regulator with RING finger domain protein 1
    Names
    cell growth regulatory gene 19 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360454.1 → NP_001347383.1  cell growth regulator with RING finger domain protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131586, AK030755, BY098099, BY237281, CJ157211
      Conserved Domains (2) summary
      COG5574
      Location:224 → 318
      PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      cd16787
      Location:272 → 308
      mRING-HC-C3HC5_CGRF1; Modified RING finger, HC subclass (C3HC5-type), found in cell growth regulator with RING finger domain protein 1 (CGRRF1) and similar proteins

    2. NM_001360455.1 → NP_001347384.1  cell growth regulator with RING finger domain protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK004156, AK030755, BY237281, BY704400, CJ157211
      Consensus CDS
      CCDS88640.1
      UniProtKB/TrEMBL
      A0A2I3BR24
      Related
      ENSMUSP00000154423.2, ENSMUST00000140114.3

    3. NM_026832.4 → NP_081108.2  cell growth regulator with RING finger domain protein 1 isoform 1

      See identical proteins and their annotated locations for NP_081108.2

      Status: VALIDATED

      Source sequence(s)
      AC131586, AK030755, BY237281, CJ157211
      Consensus CDS
      CCDS26981.1
      UniProtKB/Swiss-Prot
      Q3U3F1, Q8BMJ7, Q8CI24
      Related
      ENSMUSP00000070548.9, ENSMUST00000068532.10
      Conserved Domains (1) summary
      pfam13920
      Location:270 → 315
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      47069591..47091655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMJ7.1 GenPept UniProtKB/Swiss-Prot:Q8BMJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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